Go Back   Science Forums Biology Forum Molecular Biology Forum Physics Chemistry Forum > Molecular Research Topics Forum > Molecular Biology Articles and Protocols
Register Search Today's Posts Mark Forums Read

Molecular Biology Articles and Protocols Post Molecular Biology and science Protocols, Reviews, and Articles Forum. You can be the author!

New 1 letter code for amino acids

New 1 letter code for amino acids - Molecular Biology Articles and Protocols

New 1 letter code for amino acids - Post Molecular Biology and science Protocols, Reviews, and Articles Forum. You can be the author!

LinkBack Thread Tools Display Modes
Old 08-01-2009, 10:21 AM
Pipette Filler
Points: 58, Level: 1 Points: 58, Level: 1 Points: 58, Level: 1
Activity: 0% Activity: 0% Activity: 0%
Join Date: Aug 2009
Location: Berlin/Germany
Posts: 3
Thanks: 0
Thanked 0 Times in 0 Posts
Post New 1 letter code for amino acids

New easy-to-memorize 1-letter code for amino acids
by Dr. rer. nat. Peter Erich Keller
Member of the International Union of Crystallography
Member of the European Peptide Society

A new easy-to-memorize 1-letter code for amino acids is proposed. To obtain good readability, additionally Greek letters, the Swedish letter , the Latin combined letter and the @ symbol from the internet are used. This new 1-letter code shows considerable advantages over the old one and might be chosen as new standard coding.

Amino acid 3-letter 1-letter new 1-letter
code [1] code [1] code

Alanine Ala a @ alanine
Arginine Arg r arginine
Asparagine Asn n asparagine
Aspartic acid Asp d a aspartic acid
Cysteine Cys c c cysteine
Glutamic acid Glu e g glutamic acid
Glutamine Gln q q glutamine
Glycine Gly g γ glycine
Histidine His h h histidine
Isoleucine Ile i i isoleucine
Leucine Leu l l leucine
Lysine Lys k λ lysine
Methionine Met m m methionine
Phenylalanine Phe f φ phenylalanine
Proline Pro p p proline
Serine Ser s s serine
Threonine Thr t θ threonine
Tryptophan Trp w τ tryptophan
Tyrosine Tyr y t tyrosine
Valine Val v v valine

Unknown x ξ unknown

An example taken from the NCBI [2] peptide sequence database is given. The proinsulin precursor (Homo sapiens) peptide sequence is translated in the new easy-to-memorize 1-letter code. The readability is greatly enhanced in comparison to the old 1-letter code. Even a secondary structural element, an α-helical region, can be estimated from the new 1-letter code, see amino acids #21 to #25, by usage of the at symbol for the good α-helix builder alanine [3]. For coding phenylalanine, the chemical abbreviation for the phenyl group φ is used. Threonine is coded by the Greek letter θ (.theta.) with first and second letter in coincidence with its name. All amino acids with the first letter A in their names are coded by an a containing 1-letter code: @, , , a.

NCBI Reference Sequence: NP_000198.1
proinsulin precursor [Homo sapiens]
1 malwmrllpl m@lτmllpl
11 lallalwgpd l@ll@lτγpa
21 paaafvnqhl p@@@φvqhl
31 cgshlvealy cγshlvg@lt
41 lvcgergffy lvcγgγφφt
51 tpktrreaed θpλθg@ga
61 lqvgqvelgg lqvγqvglγγ
71 gpgagslqpl γpγ@γslqpl
81 alegslqkrg @lgγslqλγ
91 iveqcctsic ivgqccθsic
101 slyqlenycn sltqlgtc

[1] Cooper, G. M.; Hausman, R. E. (2004). The cell: a molecular approach (3rd ed.). Sinauer. p. 51.
[2] National Center for Biotechnology Information, National Library of Medicine, Bethesda MD, U.S.A.
[3] Quellre, P. (Keller, P.) 2007, Why is alanine such a good α-helix builder, virtual poster presented at the European Crystallographic Meeting ECM24, Morocco, Marrakes
Reply With Quote

acids , amino , code , letter

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Trackbacks are On
Pingbacks are On
Refbacks are On

Forum Jump

Similar Threads
Thread Thread Starter Forum Replies Last Post
Some amino acids questions mathbeauty Biochemistry Forum 1 09-06-2009 07:28 PM
Variety Cultivar or Form, how do I know ? Duncan Botany Forum 13 10-28-2005 08:49 PM
Fatty acids: analysis techniques? Bruce Hamilton Chemistry Forum 2 07-20-2003 12:17 PM

All times are GMT. The time now is 11:39 PM.

Powered by vBulletin® Version 3.8.4
Copyright ©2000 - 2015, Jelsoft Enterprises Ltd.
Copyright 2005 - 2012 Molecular Station | All Rights Reserved
Page generated in 0.11874 seconds with 16 queries