Hi, I am doing my A level biology coursework. I am struggling to find out
why streptomycin is more effective at inhibiting the growth of Gram negative
bacteria (E coli) than at inhibiting the growth of gram postive bacteria (B
Subtilis). I know about how the antibitoic wokrs, (inhibiting protein synthesis
etc) but can not link this to why the effectiveness differs upon the type of
Any help would eb appreciated and included in my bibiliography. thankyou
On Wed, 2 Apr 2008 09:59:31 EDT, [Only registered users see links. ] wrote:
It _might_ be for any of the reasons why bacteria can be Str-R
Ribosome not affected.
That is, they might be resistant at most any step. A priori there is
no particular way to know.
My memory says that uptake is the issue in this case. Please check
that -- but you may need to go to the older literature to find anyone
who bothers to say.
Let's see.. The msg title suggests you are in high school. Do you have
access to a college library -- with a reference librarian who can help
with the search? If not... Try PubMed, and even Google. Maybe even
google on "Why are aminoglycosides more effective against gram
negative bacteria". Play around.
Always be careful with such generalities. Str was much used against
tuberculosis in the old days.