Orbifloxacin

Hi again,

does anyone has experience with orbifloxacin or quinolone like
antibiotics. I will have to do some studies in which I must be able to
isolate microorganisms from medical products containing orbifloxacin,
and I have to neutralize this agent. I know that this antibiotic
inhibits the DNA-Gyrase of gram negative and positive bacteria.
Somewhere I read that bivalent kations such as Ca oder Na can decrease
the antibiotic activity. Has anyone an idea or informations for me? Is
this inhibition reaction ATP or Mg dependent? Thanks a lot in advance.


Jeff
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