QseC - A New signalling receptor in E.coli

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Bacterial new signaling Receptor for Infection.
Researchers at UT Southwestern Medical Center are the first to identify the receptor, known as QseC, used by a diarrhea-causing strain of E. coli to receive signals from human flora and hormones in the intestine (nephrine and epinephrine) and express virulence genes to initiate infection. This receptor is not only present in E.coli but it is also now reported in many other pathogenic bacteria. So we can use this knowledge to design specific antagonists to block bacterial infections.
This knowledge opens the door to further understanding of the signaling processes between microbes and humans and to the development of novel treatments of bacterial infections with antagonists to these signals.New therapies are important because treating some bacterial infections with conventional antibiotics can cause the release of more toxins and may worsen disease outcome.


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