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LC-MS (why analytes must be in ionic form?)

LC-MS (why analytes must be in ionic form?) - Mass Spectrometry Forum

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Old 02-06-2012, 11:31 AM
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Default LC-MS (why analytes must be in ionic form?)



I was told when running LC before MS analysis, pH of the solvents / eluents must be adjusted in such a way that the analytes will be in ionic form. But why, if they will be ionized after LC run?
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Old 03-16-2012, 02:49 AM
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Default Re: LC-MS (why analytes must be in ionic form?)

Have you tried any run with adjusting the pH and without adjusting the pH of the solvents?

Is there any differences in the performance?
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Old 03-21-2012, 07:38 AM
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Default Re: LC-MS (why analytes must be in ionic form?)

Quote:
Originally Posted by Selina View Post
Have you tried any run with adjusting the pH and without adjusting the pH of the solvents?

Is there any differences in the performance?
May Be u can Try.

Thank You.
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Old 06-21-2012, 06:09 PM
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Default Re: LC-MS (why analytes must be in ionic form?)

Quote:
Originally Posted by sonjalin View Post
I was told when running LC before MS analysis, pH of the solvents / eluents must be adjusted in such a way that the analytes will be in ionic form. But why, if they will be ionized after LC run?
Um...your question is a circle. You use the solvents to run the LC right?
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Old 02-11-2013, 12:26 PM
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