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EJ78 10-28-2009 12:48 PM

Glycan mass spec
 
Hi, just a quickie- do glycan groups on glycosylated peptides carry a charge when ionised by ESI-MS (or is it just the peptides)??

Pippuri 05-17-2010 02:28 AM

Re: Glycan mass spec
 
Hi EJ78,

It depends on which kind of glycan you are looking for. While many sugars do not carry any charge, some of them do (take Sialic acid for instance). Says, if the glycan part is simply the core high mannose structure, then the glycan won't contribute any charge to the glycopeptide; otherwise, if the glycan has a terminal sialic acid, then the answer will be "yes, it contributes one negative charge".

Good luck.


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