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Will a RAG knockout mouse have defective MHC class I proteins?

Will a RAG knockout mouse have defective MHC class I proteins? - Knockout Mouse Forum

Will a RAG knockout mouse have defective MHC class I proteins? - Discuss and post questions about knockout mice, transgenic mice and other transgenic animal models.


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Old 12-09-2011, 09:16 AM
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Default Will a RAG knockout mouse have defective MHC class I proteins?



Please help with this question, its not in my textbook and I'm studying for an exam. If you can provide an explanation or a source that would be great.

Thanks so much!

Mike
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Old 12-13-2011, 01:44 PM
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Default Re: Will a RAG knockout mouse have defective MHC class I proteins?

RAG KO mice will express MHC class I normally because virtually all cells express class I. Deletion of RAG1/2 of course disrupt B and T cell development, because it blocks Immunoglobulin and TCR recombination.

However, because RAG mice will lack functional CD8 T cells, the MHC classI expressed by cells will not be recognized by the immune system.
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