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#1
12-09-2011, 08:16 AM
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 Will a RAG knockout mouse have defective MHC class I proteins? Please help with this question, its not in my textbook and I'm studying for an exam. If you can provide an explanation or a source that would be great. Thanks so much! Mike  |
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#2
12-13-2011, 12:44 PM
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| Re: Will a RAG knockout mouse have defective MHC class I proteins? RAG KO mice will express MHC class I normally because virtually all cells express class I. Deletion of RAG1/2 of course disrupt B and T cell development, because it blocks Immunoglobulin and TCR recombination. However, because RAG mice will lack functional CD8 T cells, the MHC classI expressed by cells will not be recognized by the immune system. |
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| class , defective , knockout , mhc , mouse , proteins , rag |
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