Go Back   Science Forums Biology Forum Molecular Biology Forum Physics Chemistry Forum > Molecular Research Topics Forum > Animal and Molecular Model Systems > Knockout Mouse Forum
Register Search Today's Posts Mark Forums Read

Knockout Mouse Forum Discuss and post questions about knockout mice, transgenic mice and other transgenic animal models.


Knockout mice for treatments?

Knockout mice for treatments? - Knockout Mouse Forum

Knockout mice for treatments? - Discuss and post questions about knockout mice, transgenic mice and other transgenic animal models.


Reply
 
LinkBack Thread Tools Display Modes
  #1  
Old 05-21-2011, 03:16 AM
Pipette Filler
Points: 520, Level: 10 Points: 520, Level: 10 Points: 520, Level: 10
Activity: 0% Activity: 0% Activity: 0%
 
Join Date: May 2008
Posts: 4
Thanks: 0
Thanked 0 Times in 0 Posts
Default Knockout mice for treatments?



What do scientists do with a knockout mouse to research treatments for colon cancer.
Please be detailed if u can or give me a website
Reply With Quote
  #2  
Old 05-21-2011, 03:17 AM
Pipette Filler
Points: 2, Level: 1 Points: 2, Level: 1 Points: 2, Level: 1
Activity: 0% Activity: 0% Activity: 0%
 
Join Date: May 2011
Posts: 1
Thanks: 0
Thanked 0 Times in 0 Posts
Default

Knock-out mice are used in colorectal cancer research.
Knock-out means that the mice have certain genes turned off through a targeted mutation. So because of this all the cells of those mice can't express that gene like it normally would.
In this case APC gene is turned off.
This adenomatous polyposis coli (APC) gene is classified as a tumor supressor gene. That means it prevents the uncontrolled growth of cells that may result in cancerous tumors.
So these Knock-out mice have a considerably higher risk for colon cancer because the lack of tumor supressor gene in there colon.
I hope this helps.
Reply With Quote
Reply

Tags
knockout , mice , treatments


Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Trackbacks are On
Pingbacks are On
Refbacks are On

Forum Jump

Similar Threads
Thread Thread Starter Forum Replies Last Post
What is the role of thymidine kinase in the production of knockout mice? Sam S Knockout Mouse Forum 0 05-21-2011 03:03 AM
knockout mice or reporter mice? Genetikci Knockout Mouse Forum 1 08-28-2009 09:48 PM
Knockout mice in medical research holdshiftpress8 Knockout Mouse Forum 2 01-25-2008 03:40 PM
Knockout Mice Gene Targeting Nobel Prize 2007 Videos winselvam Knockout Mouse Forum 0 11-14-2007 08:49 AM
what is knockout mice? khai07@btinternet.com Knockout Mouse Forum 1 04-19-2007 05:04 PM


All times are GMT. The time now is 01:51 PM.


Powered by vBulletin® Version 3.8.4
Copyright ©2000 - 2014, Jelsoft Enterprises Ltd.
Copyright 2005 - 2012 Molecular Station | All Rights Reserved
Page generated in 0.11402 seconds with 16 queries