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What is the role of thymidine kinase in the production of knockout mice?

What is the role of thymidine kinase in the production of knockout mice? - Knockout Mouse Forum

What is the role of thymidine kinase in the production of knockout mice? - Discuss and post questions about knockout mice, transgenic mice and other transgenic animal models.


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Old 05-21-2011, 03:03 AM
Pipette Filler
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Default What is the role of thymidine kinase in the production of knockout mice?



What is the role of thymidine kinase in the production of knockout mice?
(A) Helps DNA to integrate by homologous recombination.
(B) Prevents DNA replication in the presence of the drug gancyclovir, enabling selection of homologous
recombination events over random integration.
(C) Disrupts function of the chosen gene by interrupting transcription by RNA polymerase.
(D) Confers antibiotic resistance, allowing selection of embryonic stem (ES) cells containing the targeting
vector.
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