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| Knockout Mouse Forum Discuss and post questions about knockout mice, transgenic mice and other transgenic animal models. |
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| About KOMP The Knockout Mouse Project (KOMP) is a trans-NIH initiative that aims to generate a comprehensive and public resource comprised of mouse embryonic stem (ES) cells containing a null mutation in every gene in the mouse genome. The combined collection of mouse ES cells with knockouts in 8,500 genes will be useful for producing knockout mice. The NIH KOMP initiative aims to: 1.use gene targeting to make the resource of null alleles, marked with a high utility reporter, preferably in C57BL/6; 2.support a repository to house the products of this resource as well as an additional repatriation' effort to bring into repositories 1000 of the existing high priority mouse knockouts not already stored in a public repository; 3.develop improved C57BL/6 ES cells that show robust germline transmission, so that they may be used in a high throughput pipeline in generating this resource; and 4.implement a data coordination center which will make the status and relevant data of the production effort available to the research community. |
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