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When making a transgenic mouse, why can't you just mate 2 chimeric mice?

When making a transgenic mouse, why can't you just mate 2 chimeric mice? - Knockout Mouse Forum

When making a transgenic mouse, why can't you just mate 2 chimeric mice? - Discuss and post questions about knockout mice, transgenic mice and other transgenic animal models.


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Old 10-24-2008, 04:51 PM
Pipette Filler
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Default When making a transgenic mouse, why can't you just mate 2 chimeric mice?



I read that when making a knockout mouse, you have to mate 1 chimeric mouse with a wildtype to generate a heterozygous mutant before mating that heterozygous mutant with another to generate the homozygous mutant. So my question is why can't you just breed 2 chimeric mice from the start, why is it necessary to go through such a long process? Thank you!
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