Go Back   Science Forums Biology Forum Molecular Biology Forum Physics Chemistry Forum > General Forum > Molecular Biology News and Announcements > Instructions for Posting, Help, and Frequently Asked Questions
Register Search Today's Posts Mark Forums Read

Instructions for Posting, Help, and Frequently Asked Questions Instructions for Posting, Help, and Frequently Asked Questions. If you aren't sure how to start a new thread or post messages check here!


grant writing help

grant writing help - Instructions for Posting, Help, and Frequently Asked Questions

grant writing help - Instructions for Posting, Help, and Frequently Asked Questions. If you aren't sure how to start a new thread or post messages check here!


Reply
 
LinkBack Thread Tools Display Modes
  #1  
Old 01-04-2009, 12:28 AM
Pipette Filler
Points: 41, Level: 1 Points: 41, Level: 1 Points: 41, Level: 1
Activity: 0% Activity: 0% Activity: 0%
 
Join Date: Jan 2009
Posts: 2
Thanks: 0
Thanked 0 Times in 0 Posts
Default grant writing help



Iam writing a grant in the field of molecular biology regarding a protein . There is no information about its function. Iam testing it as a marker for a chemotherapy. I have no experience in this field. So the question is - if the proposed hypothesis is not achieved and all i can say is it cannot be used as a marker(since no other information on its function), is it essential to have a backup plan ?
Reply With Quote
  #2  
Old 04-19-2010, 01:46 AM
Banned
Points: 122, Level: 2 Points: 122, Level: 2 Points: 122, Level: 2
Activity: 0% Activity: 0% Activity: 0%
 
Join Date: Apr 2010
Posts: 30
Thanks: 0
Thanked 0 Times in 0 Posts
Default Re: grant writing help

Great content and very helpful thank and keep up the good work.
Reply With Quote
  #3  
Old 04-19-2010, 03:43 PM
danfive's Avatar
Nobel Laureate
Points: 8,612, Level: 64 Points: 8,612, Level: 64 Points: 8,612, Level: 64
Activity: 0% Activity: 0% Activity: 0%
 
Join Date: Jul 2007
Location: Houston TX
Posts: 969
Thanks: 12
Thanked 184 Times in 154 Posts
Smile Re: grant writing help

Quote:
Originally Posted by grad View Post
Iam writing a grant in the field of molecular biology regarding a protein . There is no information about its function. Iam testing it as a marker for a chemotherapy. I have no experience in this field. So the question is - if the proposed hypothesis is not achieved and all i can say is it cannot be used as a marker(since no other information on its function), is it essential to have a backup plan ?
So you have a way to identify this marker-protein. Then you need a way to measure quantitatively the protein from well documented clinical samples.

That way you can run statistics, like roc curves, to determine the markers ability to predict health status. Path reports, medications, times of collections are all important.

So get yourself an antibody for this marker, plus a plan to collect the clinical samples. The more sub-groups in the clinical data (and reasonably sized sample sets) the more likely your marker will have some correlation to disease or treatment outcome.

Good luck.
Reply With Quote
  #4  
Old 04-19-2010, 03:52 PM
Warthaug's Avatar
Post-Doc
Points: 2,383, Level: 31 Points: 2,383, Level: 31 Points: 2,383, Level: 31
Activity: 0% Activity: 0% Activity: 0%
 
Join Date: Sep 2009
Location: London, Canada
Posts: 203
Thanks: 1
Thanked 68 Times in 61 Posts
Default Re: grant writing help

Quote:
Originally Posted by grad View Post
Iam writing a grant in the field of molecular biology regarding a protein . There is no information about its function. Iam testing it as a marker for a chemotherapy. I have no experience in this field. So the question is - if the proposed hypothesis is not achieved and all i can say is it cannot be used as a marker(since no other information on its function), is it essential to have a backup plan ?
You do not need to know the function of a protein to study it, either as a marker, or for functionality (in fact, if we did this science would go no where). But I would assume that there is some reason why you suspect it would be a good marker - previous data showing an association with cancer/chemo, or perhaps a structural similarity to another protein which is linked to cancer/chemo. Just picking a protein at random is not a good idea; but even a weak basis for your choice will generate a lot more "cred" with the grant reviewers.

As for backup plans, you should always have one or two. In my experience, somewhere between 75% and 95% or proposed hypothesis will be wrong. As such you need to have alternate ideas and research plans to account for the inevitable incorrect hypothesis. Usually I explain my main idea, and then finish off that section of the grant with a paragraph or two describing other possibilities and how I would go about testing those alternate hypothesis.

Bryan

PS: is this for a class, or is it a real grant/fellowship application?
__________________
[Only registered users see links. ], here at Molecular Station.
Reply With Quote
Reply

Tags
grant , writing


Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Trackbacks are On
Pingbacks are On
Refbacks are On

Forum Jump

Similar Threads
Thread Thread Starter Forum Replies Last Post
Phd dissertation help dissert99 Article Discussion 1 03-10-2011 06:08 AM
Do not make Medical Writing your headache............. Priti Microbiology Forum 0 04-12-2008 01:07 PM
Effective Medical Writing Service............... Priti Microbiology Forum 0 03-05-2008 04:43 AM
Writing an Experimental Section James Stokes Chemistry Forum 9 11-21-2003 07:29 PM


All times are GMT. The time now is 11:26 PM.


Powered by vBulletin® Version 3.8.4
Copyright ©2000 - 2014, Jelsoft Enterprises Ltd.
Copyright 2005 - 2012 Molecular Station | All Rights Reserved
Page generated in 0.13413 seconds with 16 queries