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BCG Asthma Antibiotics Th1/Th2

BCG Asthma Antibiotics Th1/Th2 - Immunology and Host-Pathogen Interactions

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Old 11-02-2008, 04:11 AM
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Default BCG Asthma Antibiotics Th1/Th2



I realize the model of th1/th2 is not perfect.
Vaccines are said to be very strong initiators of a th2 preference that could eventually polarize into permanent dominance, there are primary sources that state this.

So how does BCG differ as it causes a th1 response (or at least IFN-y) How is this possible when other bacterial vaccines shift to Th2?

Antibiotics are said to generally cause th2 dominant diseases such as asthma.
But certain antibiotics stimulate Th1 production, ifn-y etc. (macrolides from what I've read).
May this just be a modulatory shift that would cease when they are stopped?
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