Carbon Monoxide Protects Lung Cells Against Oxygen-induced Damage

[moleculardude]

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Researchers at the University of Pittsburgh have demonstrated that low-dose carbon monoxide administered in conjunction with oxygen therapy markedly inhibits oxygen-induced damage to lung cells. These findings, being reported in the January 19 issue of the Journal of Biological Chemistry, have significant implications for the treatment of acute respiratory distress syndrome, or ARDS, according to the study's authors.

[kali17tt]

Very interesting,
I get that hyperoxia causes a significant alveolar-capillary leakage but since hemoglobin has a higher affinity for carbon monoxide than oxygen would this significantly effect oxygen consumption or PaO2? What other side effects would this have to a critically ill person with ARDS? Would a contraindication be sickle cell anemia or decreased hemoglobin or things that increase O2 consumption like seizure activity????

Is carbon monoxide better than PEEP therapy which causes overdistention, barotrauma and or decrease in venous return?

hummmmm Only time will tell I guess...

[Cool man]

Great content and very helpful thank and keep up the good work.