How Eating Less Might Make You Live Longer

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How Eating Less Might Make You Live Longer

Caloric restriction in non-obese people translates into less oxidative damage in muscle cells, according to a new study by Anthony Civitarese, Eric Ravussin and colleagues (Pennington Biomedical Research Center). As oxidative damage has been linked to aging, this could explain how limiting calorie intake without malnutrition extends life span.

[danfive]

I recently interviewed with a researcher that uses mouse models to explore calorie restriction and longevity. His theory is a little more complicated than limiting oxidative damage, it has to do with a whole activated pathway exclusively turned on in calorie restricted mice and not turned on in regular fed mice. He believes he has found a crucial gene (and the activated mutant version) that he can insert into regular mice and then get mice with the longevity trait and no need for calorie restriction. Pretty interesting but too much biochem for me to remember accurately from such a brief meeting.