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Gene Therapy Discuss gene therapy issues, methods and protocols for viral gene therapy, problems and solutions.


The future of Gene Therapy - Viral or Non-Viral

The future of Gene Therapy - Viral or Non-Viral - Gene Therapy

The future of Gene Therapy - Viral or Non-Viral - Discuss gene therapy issues, methods and protocols for viral gene therapy, problems and solutions.


View Poll Results: Will gene therapy for human use be viral based or non-viral?
Viral - gene therapy in humans will use viruses 2 50.00%
Non-viral - gene therapy in humans will NOT use viruses 0 0%
Both - Both will be successful as gene therapy treatments 2 50.00%
Neither - Gene therapy is nothing but a dream. 0 0%
Voters: 4. You may not vote on this poll

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  #1  
Old 11-02-2010, 09:01 PM
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Default The future of Gene Therapy - Viral or Non-Viral



Without too much discussion on the matter (I don't want to accidentally say anything to bias my audience), I was wondering what you all think the future of gene therapy will be for human therapies - viral, non-viral, both?

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  #2  
Old 11-02-2010, 09:44 PM
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Default Re: The future of Gene Therapy - Viral or Non-Viral

probably something like the lipoparticle, siRNA (remember no cures, just treatments), stem-cell like (person's own tissue modified then re-implanted).
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Old 11-03-2010, 12:55 PM
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Default Re: The future of Gene Therapy - Viral or Non-Viral

Going to be a mix, IMO. Viruses remain the only way we can significantly modify a large number of cells in adults, but likewise will also remain risky. Other techniques are better in some cases, and worse in others. Gene therapy is, and will continue, to occur. But no one toolbox will dominate - we'll use what is best for the specific conditions at hand.

Bryan
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Old 08-06-2011, 02:40 AM
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Default Re: The future of Gene Therapy - Viral or Non-Viral

I believe that with advances in genetic engineering to develop efficient viral vectors for use in gene therapy are possible and eliminate some limiting factors of this kind of vector.
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Old 08-19-2013, 08:51 AM
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Default Re: The future of Gene Therapy - Viral or Non-Viral

In fall 2012, the European Medicines Agency (EMA) approved the modified adeno-associated virus AAV-LPL S447X as the first-ever gene therapy for clinical use in the Western world. The viruses modified for gene therapy cannot integrate their DNA into the host cell genome, because they lack a particular enzyme needed for this. Is excluded also that AAV-LPL S447X tends to integrate at sites in the genome where this integration might activate cancer-promoting genes. In most cases, the viral genome persists in the cytoplasm as a separate structure. If it is integrated, this happens at random sites. This modified adeno-associated virus has been observed that he integrates into the mitochondrial genome. The developed AAV-LPL S447X was used for the treatment of a rare inherited metabolic disease called lipoprotein lipase deficiency (LPLD). In future, AAV-LPLS447X shall be used as a viral vector to deliver an intact gene copy to affected cells for several neurodegenerative diseases.
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