Brain mechanisms of social anxiety disorder

Leider bietet weder die elektronische Zeitschriftenbibliothek in DA, FFM
oder MZ folgendes elektronische Medium an: "Journal of Clinical
Psychiatry" :-(((

Waere jemand,dessen Bib jene E-Zeitschrift hat, mal so nett und koennte
mir die PDF Datei des folgenden Abstracts an obige Emailadresse
zusenden? (Falls die Datei groesser als 2MB sein sollte, bitte vorher
Bescheid sagen, da ich dann eine andere Email einrichten muss).

Abstract:

J Clin Psychiatry. 1998;59 Suppl 17:4-11.

Brain mechanisms of social anxiety disorder.

Nutt DJ, Bell CJ, Malizia AL.

Psychopharmacology Unit, University of Bristol, United Kingdom.

The neurobiology of social anxiety disorder is poorly understood,
although
preliminary research has suggested several possible biological
abnormalities.
Challenge studies have demonstrated that subjects with social anxiety
disorder
have a sensitivity to carbon dioxide, cholecystokinin, and caffeine
somewhere
between that of panic disorder patients and normal controls.
Serotonergic
pathways may play a role in social anxiety disorder, as shown by the
clinical
effectiveness of selective serotonin reuptake inhibitors, plus
fenfluramine and
m-chlorophenylpiperazine challenge studies. Dopaminergic function and
striatal
dopamine uptake appear to be reduced in social anxiety disorder. There
is also
evidence for cardiovascular and adrenergic abnormalities. Recently,
positron
emission tomography has begun to identify brain regions that appear to
be
uniquely activated in this condition. These results offer the promise of
an
understanding of the brain mechanisms of social anxiety disorder, but
much
further research is needed to fully elucidate the neurobiological
cause(s) that
exist.

Publication Types:
Review
Review, Tutorial

PMID: 9811424 [PubMed - indexed for MEDLINE]


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