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what is h3k4, h3k27?

what is h3k4, h3k27? - Epigenetics Forum: DNA Methylation, Histone and Chromatin Study

what is h3k4, h3k27? - An Epigenetics Forum Dealing with DNA Methylation, the study of histones and chromatin


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Old 01-30-2011, 05:08 AM
Pipette Filler
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Default what is h3k4, h3k27?



Hi,

I am new to the world of chromatin. In my readings, I come across terms like H3K4, H3k27, h3k36, but cannot find what they mean. Can someone help me figure this out or suggest a resource? Also, how does one determine where to investigate on the chromatin - is it by Chip-seq?

Thanks.
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Old 01-31-2011, 06:47 PM
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Default Re: what is h3k4, h3k27?

H3 means the number of histone, and K (or whatever letter is) means the aminoacid. In this case K is for lysine. In other words, H3K4 means histone 3 lysine 4 and so on.

Here's the link where I got the clue:

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Old 08-17-2011, 05:41 AM
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Default Re: what is h3k4, h3k27?

Methylation of histone H3 lysine 27 (H3K27) is a posttranslational modification that is highly correlated with genomic silencing.
(It is similar with H3K4 OR K36, I think.)

Published Online 30 August 2007
Science 19 October 2007:
Vol. 318 no. 5849 pp. 447-450
DOI: 10.1126/science.1149042
•Report
Demethylation of H3K27 Regulates Polycomb Recruitment and H2A Ubiquitination
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Old 03-13-2012, 10:39 AM
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Default Re: what is h3k4, h3k27?

In this case you can also find terms like H3K9me2 - and the 'me2' means dimethylation Sometimes shortcut 'ac' is also useful (it means acetylation)
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Old 05-10-2012, 10:29 AM
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Default Re: what is h3k4, h3k27?

In this case you can also find terms like H3K9me2 - and the 'me2' means dimethylation Sometimes shortcut 'ac' is also useful (it means acetylation)
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