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jiji324 07-04-2008 09:46 AM

DNA Base Pairing Always GC AT?
 
Hi is DNA Base Pairing Always GC AT? or can there sometimes be differences in DNA?

ethidiumbromide 07-04-2008 07:38 PM

Re: DNA Base Pairing Always GC AT?
 
In general, yes it is always GC AT. This matching has to do with how the molecules fit together and a mismatch will cause a "bump" in the DNA. Usually when there is a mismatch it is done during copying, and one of the pair will be excised and replaced with the appropriate nucleotide. If the mismatch were to remain, it would be considered a bad mutation. Like something you would find in cancer cells.

dna_pol3 09-04-2008 04:20 PM

Re: DNA Base Pairing Always GC AT?
 
Quote:

Originally Posted by jiji324 (Post 8255)
Hi is DNA Base Pairing Always GC AT? or can there sometimes be differences in DNA?

yes always is CG AT bcz of hydrogen biding between them. if it is not like this it is called mutation.
good luck

olenka 09-18-2008 12:00 AM

Re: DNA Base Pairing Always GC AT?
 
It should always be CG (triple hydrogen bonds) and AT (double hydrogen bonds ) if not Then mutation occurs.

af malik 09-20-2008 05:01 AM

Re: DNA Base Pairing Always GC AT?
 
Hi,
DNA base pairing is always GC n AT and this exect base pairing is crusical for the formation of MAJOR and MINOR grooves of DNA which in turns help to regulate the GENE EXPRESSION when DNA binding proteins bind with these major and minor grooves due to the availability of different DONOR and ACCEPTOR groups in these grooves due to exect GC and AT base pairing otherwise the mismatch base pairing lead to mutations but mutation rates are very low as nature has laid many DNA repair systems in our genome, if by-chance there is mismatch base pairing during replication then it is detected immediately, excised n repair by these systems.for mutation it should be enough to cause harmness.
with best wishes,
af malik.


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