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DNA Forum Discuss DNA, the molecule of hereditary. Topics include DNA structure, DNA replication, DNA function.


A DNA light switch

A DNA light switch - DNA Forum

A DNA light switch - Discuss DNA, the molecule of hereditary. Topics include DNA structure, DNA replication, DNA function.


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Old 07-26-2007, 02:30 PM
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Cool A DNA light switch



Researchers in Japan have created a molecular padlock that can lock onto sections of DNA and be unlocked on command. The padlock obstructs DNA-cleaving enzymes and could potentially be used to halt gene transcription.


"Padlock probes can act as inhibitors to block the DNA-protein interaction required for transcriptional initiation"
- Kenzo Fujimoto

Reversible photopadlocking on double-stranded DNA
Kenzo Fujimoto, Shigeo Matsuda, Yoshinaga Yoshimura, Takehiro Ami and Isao Saito, Chem. Commun., 2007, 2968
DOI: 10.1039/b707524c
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Old 08-05-2007, 05:57 AM
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Smile Re: A DNA light switch

Thanks a lot for the nice article.
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Old 10-12-2008, 10:17 AM
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Default Re: A DNA light switch

Thank you for updating us
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