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moleculardude 07-26-2007 02:30 PM

A DNA light switch
 
Researchers in Japan have created a molecular padlock that can lock onto sections of DNA and be unlocked on command. The padlock obstructs DNA-cleaving enzymes and could potentially be used to halt gene transcription.


"Padlock probes can act as inhibitors to block the DNA-protein interaction required for transcriptional initiation"
- Kenzo Fujimoto

Reversible photopadlocking on double-stranded DNA
Kenzo Fujimoto, Shigeo Matsuda, Yoshinaga Yoshimura, Takehiro Ami and Isao Saito, Chem. Commun., 2007, 2968
DOI: 10.1039/b707524c

aelshafey 08-05-2007 05:57 AM

Re: A DNA light switch
 
Thanks a lot for the nice article.:)

Monem 10-12-2008 10:17 AM

Re: A DNA light switch
 
Thank you for updating us


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