Go Back   Science Forums Biology Forum Molecular Biology Forum Physics Chemistry Forum > General Science Forums > Biochemistry Forum > DNA Forum
Register Search Today's Posts Mark Forums Read

DNA Forum Discuss DNA, the molecule of hereditary. Topics include DNA structure, DNA replication, DNA function.


If an incorrect nucleotide is incorporated into a...

If an incorrect nucleotide is incorporated into a... - DNA Forum

If an incorrect nucleotide is incorporated into a... - Discuss DNA, the molecule of hereditary. Topics include DNA structure, DNA replication, DNA function.


Reply
 
LinkBack Thread Tools Display Modes
  #1  
Old 03-30-2007, 01:12 AM
Tia Tia is offline
Pipette Filler
Points: 1,342, Level: 21 Points: 1,342, Level: 21 Points: 1,342, Level: 21
Activity: 0% Activity: 0% Activity: 0%
 
Join Date: Mar 2007
Posts: 1
Thanks: 0
Thanked 0 Times in 0 Posts
Default If an incorrect nucleotide is incorporated into a...



...forming strand of DNA? Will this mistake be transmitted to the next generation of DNA molecules that forms from this strand???
Reply With Quote
  #2  
Old 03-30-2007, 02:00 AM
Pipette Filler
Points: 1,326, Level: 21 Points: 1,326, Level: 21 Points: 1,326, Level: 21
Activity: 0% Activity: 0% Activity: 0%
 
Join Date: Mar 2007
Posts: 2
Thanks: 0
Thanked 0 Times in 0 Posts
Default

It depends. DNA had excellent proofreading systems that double check nucleotide sequences. If an incorrect nucleotide is entered in a new strand, then, a polymerase should come along and fix it before it's completely separated. If the incorrect nucleotide is missed (this happens about once ever 1,000,000 times) then yes, it'll be put into the next generation.
Reply With Quote
  #3  
Old 03-30-2007, 02:45 AM
Pipette Filler
Points: 1,326, Level: 21 Points: 1,326, Level: 21 Points: 1,326, Level: 21
Activity: 0% Activity: 0% Activity: 0%
 
Join Date: Mar 2007
Posts: 1
Thanks: 0
Thanked 0 Times in 0 Posts
Default

Not necessarily. One must consider spliceosomes which determine the exons and introns of a given genetic strand and thereby determine whether that particular portion with the error will be included to be replicated. Also DNA replicase and several other proteins involved in replication will need to miss this error in order for it to be transmitted to the next generation (DNA polymerase for example is known for excision repair, whereby it cuts out the incorrect nucleotide and puts in the correct one with the help of ligase). Likewise this nucleotide may not be on the template strand, which is the DNA segment used to generate copies. DNA in general is copied continuously and when an error is spotted it is often ignored because another strand is used in its stead or endonucleases may cut up this now error-riddled segment. (I am purposely circumlocuting the fact that many mistakes are utterly irrelevant because of the redundancy of DNA strands)
Reply With Quote
  #4  
Old 03-30-2007, 03:33 AM
Pipette Filler
Points: 1,326, Level: 21 Points: 1,326, Level: 21 Points: 1,326, Level: 21
Activity: 0% Activity: 0% Activity: 0%
 
Join Date: Mar 2007
Posts: 1
Thanks: 0
Thanked 0 Times in 0 Posts
Default

it's a mutation
some can be transmitted and others not
Reply With Quote
Reply

Tags
incorporated , incorrect , nucleotide


Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Trackbacks are On
Pingbacks are On
Refbacks are On

Forum Jump

Similar Threads
Thread Thread Starter Forum Replies Last Post
PCR linear DNA single nucleotide mutation wolfmiffy PCR - Polymerase Chain Reaction Forum 0 10-21-2008 03:21 PM
Why kanamycin causes more Phe than Leu to be incorporated into proteins in cell free system? Simon Protocols and Methods Forum 1 12-14-2005 06:52 PM
Nucleotide coding for organismal traits/processes Brandon Microbiology Forum 9 10-28-2004 06:47 AM
How to design nucleotide disposition order for pyrosequencing Chang Zhu Protocols and Methods Forum 0 10-03-2004 01:07 AM
SEQtools, a comprehensive software package for nucleotide and protein sequence analysis S.W. Rasmussen Forum Biologie 0 11-18-2003 09:10 AM


All times are GMT. The time now is 04:01 PM.


Powered by vBulletin® Version 3.8.4
Copyright ©2000 - 2014, Jelsoft Enterprises Ltd.
Copyright 2005 - 2012 Molecular Station | All Rights Reserved
Page generated in 0.13084 seconds with 16 queries