EMBO | EMBL Symposium: Tumour Microenvironment and Signalling
A. Burns, P. Pandolfi, B. Pauly
EMBL Heidelberg, Germany
7 - 10 May 2014
Registration deadline 27 March 2014
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Why you should attend
Since the description of the first proto-oncogenes Src, Myc, Jun and Ras, many other oncogenes and tumour suppressor genes have been identified. The respective proteins regulate key cellular growth and death pathways. Dysregulation allows oncogenes and tumour suppressor genes to transform mammalian cells and cancers arise in conditions where multiple such events are juxtaposed. Many proto-oncogenes and tumour suppressors have been mapped to canonical signalling pathways, providing a more holistic view of growth control mechanisms and paving the way for systems level analysis of cancer mechanisms.
It has also been found that some cancer cells, called cancer stem cells, retain the ability to self renew and to give rise to all cell types in a particular cancer. While the inappropriate signalling within cancer cells is well studied, an emerging concept is that tumours strongly depend on external signals for maintenance and expansion. To fully understand tumour development and progression, a deeper knowledge of the cross-talk between tumour cells and their microenvironment and the interactions between cancer cells and cancer stem cells is needed. Therefore the proposed meeting will focus on how the microenvironment influences tumour development.