EMBL Conference: The Complex Life of mRNA: From Synthesis to Decay

[EMBL]

Location & Date: 18 - 20 March 2010, Advanced Training Centre, EMBL Heidelberg, Germany

Event website & Registration: [Only registered users see links. ]

Registration deadline: 10 January 2010

Aims
The regulation of gene expression has been studied traditionally at the level of transcription. While a few examples of translational regulation were known, they were considered interesting exceptions to the general rule of regulation at the level of RNA synthesis. However, over the last few years it has become evident that several widespread posttranscriptional, mostly cytoplasmic mechanisms have profound effects on gene expression. All of these mechanisms ultimately contribute to control protein synthesis, either directly, by affecting the rate of translation, or indirectly, by affecting the abundance of mRNA. Some of them exert a qualitative, all-or-none control, for example by complete repression or elimination of certain mRNAs, others determine the intracellular location or the cell-type in which a particular RNA is translated, and still others have a quantitative effect, controlling the amount of protein made from a certain mRNA. The analysis of some of the most exciting aspects of these cytoplasmic mechanisms of gene regulation is a major focus of this meeting. It is co-sponsored by the DFG (FOR855) and EMBL Corporate Partnership Program.

Programme

Thursday 18 March 2010

* 16:45 Registration
* 18:45 - 19:00 Welcome Remarks
* 19:00 - 21:30 Synthesis and processing of mRNA

Friday 19 March 2010

* 09:00 - 10:30 The translation machinery and its regulation by proteins
* 10:30 - 11:00 Coffee Break
* 11:00 - 12:30 The translation machinery and its regulation by proteins (cont)
* 12:30 - 14:00 Lunch Break
* 14:00 - 15:30 miRNAs: biogenesis and function
* 15:30 - 16:00 Coffee Break
* 16:00 - 17:30 miRNAs: biogenesis and function (cont)
* 17:30 - 19:30 Poster Session with Aperitif
* 20:00 Dinner

Saturday 20 March 2010

* 09:00 - 10:30 Translational regulation of Viruses and Bacteria
* 10:30 - 11:00 Coffee Break
* 11:00 - 12:30 Translational regulation of Viruses and Bacteria (cont)
* 12:30 - 13:00 Lunch Break
* 14:00 - 15:30 RNA Turnover
* 15:30 - 16:00 Coffee Break
* 16:00 - 17:30 RNA Turnover (cont)
* 17:30 - 19:30 Poster Session with Aperitif
* 20:00 Gala Dinner

Invited Speakers

Elena Conti, Max Planck Institute of Biochemistry, Germany
Patrick Cramer, University of Munich, Germany
Anne Ephrussi, EMBL Heidelberg, Germany
Witold Filipowicz, Friedrich Miescher Institute, Switzerland
Ulrike Gaul, University of Munich, Germany
Fatima Gebauer , CRG (Centre for Genomic Regulation), Spain
Matthias Gromeier , Duke University, USA
Alan Hinnebusch, National Institutes of Health, USA
Ralf Jansen, University of Tübingen, Germany
Jens Lykke-Andersen , University of California San Diego, USA
Raul Mendez, CRG (Centre for Genomic Regulation), Spain
Karla Neugebauer, Max Planck Institute of Molecular Cell Biology and Genetics, Germany
Dinshaw Patel, Sloan-Kettering Institute, USA
Sébastien Pfeffer, University of Strasbourg, France
Tom Pieler, University of Göttingen, Germany
Peter Sarnow, Stanford University, USA
Robert Singer, Yeshiva University, USA
Mikiko Siomi, Keio University, Japan
Nahum Sonenberg, McGiIl University, Canada
Bertrand Séraphin , CNRS, France
David Tollervey , University of Edinburgh, United Kingdom
Jörg Vogel, Max Planck Institute for Infection Biology, Germany