Go Back   Science Forums Biology Forum Molecular Biology Forum Physics Chemistry Forum > General Science Forums > Chemistry Forum
Register Search Today's Posts Mark Forums Read

Chemistry Forum Chemistry Forum. Discuss chemical reactions, chemistry.


Dissolution of PLGA in dichloromethane

Dissolution of PLGA in dichloromethane - Chemistry Forum

Dissolution of PLGA in dichloromethane - Chemistry Forum. Discuss chemical reactions, chemistry.


Reply
 
LinkBack Thread Tools Display Modes
  #1  
Old 02-10-2004, 09:24 PM
amelie
Guest
 
Posts: n/a
Default Dissolution of PLGA in dichloromethane



Hi,
first of all, I am not a chemist, so my question may seem dumb...!
I am trying to dissolve PLGA (ratios 85:15, 65:35, 50:50 and 75:25) in
dichloromethane (DCM). However, is it not dissolving when it is
vortexed, and I've learned that you cannot heat a mix of PLGA and
DCM.
So, what should I do??

Thanks,
a lost molecular biologist



----== Posted via Newsfeed.Com - Unlimited-Uncensored-Secure Usenet News==----
[Only registered users see links. ] The #1 Newsgroup Service in the World! >100,000 Newsgroups
---= 19 East/West-Coast Specialized Servers - Total Privacy via Encryption =---
Reply With Quote
  #2  
Old 02-10-2004, 10:13 PM
Barry
Guest
 
Posts: n/a
Default Dissolution of PLGA in dichloromethane


"amelie" <[Only registered users see links. ]-spam.invalid> wrote in
message news:40294c06_1@127.0.0.1...

Is the PLGA (this is presumably poly lactic/glycolic anhydride) actually
meant to be soluble - at the level you are using?
You could try an ultrasonic bath - this has a more severe effect on the
particles. But it also causes heating, if left too long.

Barry Hunt


Reply With Quote
  #3  
Old 02-11-2004, 02:54 AM
Muhammar
Guest
 
Posts: n/a
Default Dissolution of PLGA in dichloromethane

> So, what should I do??

1) use a better solvent (DMSO)
2) use the PLGA polymer with lower n (number of units), molecular weight


[Only registered users see links. ]lid (amelie) wrote in message news:<40294c06_1@127.0.0.1>...
Reply With Quote
  #4  
Old 02-11-2004, 04:25 AM
amelie
Guest
 
Posts: n/a
Default re:Dissolution of PLGA in dichloromethane

thanks for your suggestion, it is appreciated
however, how come so many papers mention that they dissolve PLGA in
DCM? I cannot really change solvent, since I would like to make
microspheres, and DCM is a good solvent for emulsions...

thanks!



----== Posted via Newsfeed.Com - Unlimited-Uncensored-Secure Usenet News==----
[Only registered users see links. ] The #1 Newsgroup Service in the World! >100,000 Newsgroups
---= 19 East/West-Coast Specialized Servers - Total Privacy via Encryption =---
Reply With Quote
  #5  
Old 02-11-2004, 09:25 PM
Muhammar
Guest
 
Posts: n/a
Default Dissolution of PLGA in dichloromethane

1) use the low-molecular weight PLGA polymer
2) make sure your PLGA polymer is perfectly dry. - use vacuum oven to
dry it I would expect PLGA to be hyygroscopic a bit.

[Only registered users see links. ]lid (amelie) wrote in message news:<4029ae9e$1_1@127.0.0.1>...
Reply With Quote
Reply

Tags
dichloromethane , dissolution , plga


Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Trackbacks are On
Pingbacks are On
Refbacks are On

Forum Jump

Similar Threads
Thread Thread Starter Forum Replies Last Post
Fungus dissolution burghwolfe Biochemistry Forum 1 11-26-2008 02:49 AM
Chemistry Problem: What is the net ionic equation of a dissolution of salt in water? Lola M Chemistry Forum 0 10-27-2008 09:17 PM
chimie de l'eau/ dissolution du CO2 rouzic Forum De Chimie 1 04-29-2004 09:16 AM
Dissolution CO2 / Loi de Henry Guillaume Forum De Chimie 9 04-21-2004 08:54 PM


All times are GMT. The time now is 08:54 AM.


Powered by vBulletin® Version 3.8.4
Copyright ©2000 - 2014, Jelsoft Enterprises Ltd.
Copyright 2005 - 2012 Molecular Station | All Rights Reserved
Page generated in 0.13472 seconds with 16 queries