Dissolution of PLGA in dichloromethane

Hi,
first of all, I am not a chemist, so my question may seem dumb...!
I am trying to dissolve PLGA (ratios 85:15, 65:35, 50:50 and 75:25) in
dichloromethane (DCM). However, is it not dissolving when it is
vortexed, and I've learned that you cannot heat a mix of PLGA and
DCM.
So, what should I do??

Thanks,
a lost molecular biologist



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"amelie" <[Only registered users see links. ]-spam.invalid> wrote in
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Is the PLGA (this is presumably poly lactic/glycolic anhydride) actually
meant to be soluble - at the level you are using?
You could try an ultrasonic bath - this has a more severe effect on the
particles. But it also causes heating, if left too long.

Barry Hunt

> So, what should I do??

1) use a better solvent (DMSO)
2) use the PLGA polymer with lower n (number of units), molecular weight


[Only registered users see links. ]lid (amelie) wrote in message news:<40294c06_1@127.0.0.1>...

thanks for your suggestion, it is appreciated
however, how come so many papers mention that they dissolve PLGA in
DCM? I cannot really change solvent, since I would like to make
microspheres, and DCM is a good solvent for emulsions...

thanks!



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1) use the low-molecular weight PLGA polymer
2) make sure your PLGA polymer is perfectly dry. - use vacuum oven to
dry it I would expect PLGA to be hyygroscopic a bit.

[Only registered users see links. ]lid (amelie) wrote in message news:<4029ae9e$1_1@127.0.0.1>...