Anyone got any good references for the bromination of methoxy anisoles: I
want to brominate the acetophenone but I suspect the usual conditions will
remove the methyl group. I found a reference to the reaction below but the
yield was below 50 % T and it had column chromatography as a work up.
Reaction in smiles:- COC1=CC=CC=C1C(C)=O plus bromine giving
Any leads appreciated and I'm open to a discussion as to methylating the
phenol post bromination.
Thanks ... Darren.
ps for those unfamilliar with smiles:- [Only registered users see links. ]
"Muhammar" <[Only registered users see links. ]> wrote in message
Thanks for the reply. I've used dibromohydantoin a couple of times in the
past. I'll look into the conditions necessary to use this reagent ...
If you cut and paste the smiles string into the daylight webpage [Only registered users see links. ] you'll see the structure of the
compound. However, I posted the structure simply to illustrate the point
rather than to give the structure of the actual compound that I am thinking
news:<bvrbeq$gg2$[Only registered users see links. ]>...
the [Only registered users see links. ]