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Covalent modifications to improve solubility of sparingly soluble substrates

Covalent modifications to improve solubility of sparingly soluble substrates - Chemistry Forum

Covalent modifications to improve solubility of sparingly soluble substrates - Chemistry Forum. Discuss chemical reactions, chemistry.


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Old 02-02-2004, 06:51 PM
Art Ickles
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Default Covalent modifications to improve solubility of sparingly soluble substrates



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Conceptually relevant, search "biphenyl library" or "biaryl library" in a
chemistry database. DrugCo's have been making many modifications
for many years, now using "combi chem". Here's just one example:

Organ, Michael G.; Arvanitis, Elena A.; Dixon, Craig E.; Lavorato, David J.
Solution-Phase Synthesis of an Aminomethyl-Substituted Biaryl Library
via Sequential Amine N-Alkylation and Suzuki Cross-Coupling. Journal
of Combinatorial Chemistry (2001), 3(5), 473-476.




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