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Potassium Citrate / Bladder Stones

Potassium Citrate / Bladder Stones - Chemistry Forum

Potassium Citrate / Bladder Stones - Chemistry Forum. Discuss chemical reactions, chemistry.


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  #1  
Old 09-19-2003, 01:22 AM
Marshall Dermer
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Default Potassium Citrate / Bladder Stones



My dog has had calcium oxalate bladder stones and one way to
prevent them is to increase the alkilinity of his urine. The
chemical is potassium citrate which I assume is the same as:

Potassium Citrate Monohydrate (Tripotassium Citrate Monohydrate) USP Grade
C6H5K3O7-H2O
CAS 6100-05-6
F.W. 324.41
USP Grade - Granular
Minimum Assay Dried Basis: 99.0 ~ 100.5%
Loss on Drying: 3.0 ~ 6.0%
MAXIMUM LIMITS
Tartrate: To pass USP Specifications Test
Heavy Metals: 0.001%
Organic Volatile Impurities: To Pass USP Specifications Test
2.5 Kg: $70.00 USD
Disclaimer Required for New Customers and is Available Upon Request


I have found a food supplier who will provide USP granules at far
less than the cost of the powder placed in capsules. I figure I can
dissolve the granules in water and add the solution to my dog's
food when I prepare it. Here are my questions:

1. Will potassium citrate be destroyed in boiling water?

2. Will it remain stable for 2 days in the fridge when
mixed with the food?

I know the dose, can anyone think of any other problems that
I will face if I buy potassium citrate in bulk and use it
this way?

Thanks,

Marshall Dermer
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  #2  
Old 09-19-2003, 05:04 AM
hanson
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Default Potassium Citrate / Bladder Stones

"Marshall Dermer" <[Only registered users see links. ].uwm.edu> wrote in message
news:bkdlo5$btg$[Only registered users see links. ]...

This is the traditional way to deal with oxalate stones.
But check also into these two urls:
[Only registered users see links. ]
[Only registered users see links. ]
If the dog/patient has undergone antibiotic therapy or ingested
something that killed off this body resident Oxalobacter formigenes
then the loss of this bacterium from the gut flora is associated
with an increased risk of hyperoxaluria and calcium-oxalate
urolithiasis. (Kidney stones).
Check the web in which/what food this bacterium occurs in feed
it to the dog. It may be a better permanent solution then just
disolving the current stones. K-Cit is simply chelating and solubilizing
hopefully the Ca-oxalte, a temporary solution.


Buy a 50 lbs USP food grade bag of the same for the same money or less.


NO


YES


It's not a regualted chemical in any way.
It's basically lemon jucie neutralished with potash, the first squeezed
form fruit, the olther leached from the ash of burned wood.

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  #3  
Old 09-19-2003, 07:31 AM
Muhammar
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Default Potassium Citrate / Bladder Stones

The cost of active substance is always a tiny fraction of the final
price of the medication. You are smart to not to pay for the pet
product mark-up.

Citrate is perfectly stable (thermaly etc), but some microbes/mold can
probably grow in its diluted solutions over time - so make the
solution fresh every few days or keep it in fridge. (I once had an old
solution of sodium-ammonium tartarate and a nice mold growing on it.)
Dry salt will be fine - microbes will not grow in it. Heavy metals
would be concern with technical stuff - but your product specs (10 ppm
of heavy metals) looks pretty good to me.

If you do cooking for your dog, reduce the ammount of sodium (salt) he
gets - he will get a lots of potassium salt from the citrate and his
blood pressure could get rather high with additional salt. Also,
reduce the dog's intake of calcium - no bones to gnaw and no dairy
products, and let him drink all the time.

[Potassium citrate is not very alkaline itself (the taste is not as
bad as of baking soda) but gets metabolised and excreted into urine as
potassium bicarbonate.]




[Only registered users see links. ] (Marshall Dermer) wrote in message news:<bkdlo5$btg$[Only registered users see links. ]>...
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  #4  
Old 09-19-2003, 06:20 PM
Marshall Dermer
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Default Potassium Citrate / Bladder Stones

In article <[Only registered users see links. ]> Steve Turner <[Only registered users see links. ].net> writes:

The research literature suggests that calcium is not a problem.

--Marshall
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  #5  
Old 09-19-2003, 06:23 PM
Marshall Dermer
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Default Potassium Citrate / Bladder Stones

In article <N7wab.9068$[Only registered users see links. ].pas.earthlink. net> "hanson" <[Only registered users see links. ]> writes:

Thanks VERY MUCH for the lead on O. Formigenes. So far, lake sediment is
the only lead I have read on the net as a source.

I will check with the microbiologists at my university.

--Marshall
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  #6  
Old 09-19-2003, 06:32 PM
hanson
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Default Potassium Citrate / Bladder Stones

"Marshall Dermer" <[Only registered users see links. ].uwm.edu> wrote in message
news:bkfhic$ed2$[Only registered users see links. ]...
<[Only registered users see links. ]> writes:
Great, dude! Let us know what you can dig up.
To find a food source that contains/carries these bugs could
lead to a benign and preventative kidney stone therapy.
Patent the use/application of it and make a buck off it!
hanson

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  #7  
Old 09-19-2003, 08:05 PM
Marshall Dermer
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Default Potassium Citrate / Bladder Stones

In article <FYHab.8819$[Only registered users see links. ].pas.earthlink. net> "hanson" <[Only registered users see links. ]> writes:

Mr. Hanson (What is your first name?):

O. Formigenes is an anaerobic bacteria that lives in the gut. These
researchers isolated it from human feces:

[Only registered users see links. ]

--Marshall

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  #8  
Old 09-19-2003, 10:57 PM
Muhammar
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Default Potassium Citrate / Bladder Stones

Completely stable. Cooking will do nothing to citrate.

[Only registered users see links. ] (Marshall Dermer) wrote in message news:<bkfhb4$7pd$[Only registered users see links. ]>...
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  #9  
Old 09-19-2003, 11:30 PM
hanson
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Default Potassium Citrate / Bladder Stones

"Marshall Dermer" <[Only registered users see links. ].uwm.edu> wrote in message
news:bkfnj2$b2n$[Only registered users see links. ]...
Thank you for asking, but for use-net purposes such does not exist.
If you whish to contact me personally, please indicate so in a post,
give an e-mail address where you can be contacted, and I may respond.
Cool, man, thanks a mille. A first cursory glance into this paper is
however disappointing for therapeutic applications in human afflictees.
With dogs, OTOH, the gut re-colonization may be easier done, as you
could simply get stool from a healthy dog and mix some of it into
your canine's favorite food and feed it when it is very hungry, then
repeat the procedure for a weak or so and then check for results.
Meanwhile, until a more acceptable food source for humans, with O.F,
is found let us ask your for an opinion on this from our resident man,
EL Hemetis, who has a vast expertise in microbio/chem.
best regards,
hanson

cc EL
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  #10  
Old 09-20-2003, 03:16 AM
Marshall Dermer
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Default Potassium Citrate / Bladder Stones

In article <[Only registered users see links. ] > [Only registered users see links. ] (Muhammar) writes:

Thanks! --Marshall



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