matching metal ions to specific varieties of prions; Prion Disease =Metal-Ion excess malady

Last time I looked there were 8 distinct varieties of the bad prion
protein.

And it is nice that there are 2 distinct copper ions of Cu+1 and Cu+2,
and 2 distinct iron ions of Fe+2 and Fe+3, and 2 aluminum ions of Al+2
and Al+3,
and 2 zinc ions of Zn+1 and Zn+2. These metal ions are abundant in
Nature and especially in mosses and lichens chelation where grazing
animals can easily
intake these metal ions.

Has any chemist or biologist attempted to match metal ion to *specific
variety
of bad prion*?

If there is a one-to-one correspondence of match of metal ion to bad
prion would prove that prion disease is the result of the interaction of
injested metal ions in the brain tissues. And a related question: has
there been any prion victim which had not just one single variety of bad
prion but a number of different prion varieties. I suppose it would be
very easy to run an autopsy on the various metal ions present in that
diseased brain.

Which would make sense on another level in that the brain tissue is
where the most electrical activity occurrs and where the need for metal
ions is greater.

Archimedes Plutonium, [Only registered users see links. ]
whole entire Universe is just one big atom where dots
of the electron-dot-cloud are galaxies

Archimedes Plutonium wrote:

No there are not. Al2+ and Zn1+ do not exist as stable species. Neither
does uncomplexed copper (I) in water.

Rob.

Archimedes Plutonium <[Only registered users see links. ]> wrote in message news:<[Only registered users see links. ]>...

<snip garbage>

Why don't you check to see if prions are metalloprotiens first?
Were you kicked out of the Dartmouth BioChem library again?

Keep your crap out of sci.chem

Insufferable varmint.

Tony

Buckleys wrote:


Rob, I need an entire list of common metal ions found in the wild of
Nature.
Perhaps I need complexed copper and other complexed metal ions. Perhaps the
fact of complexing does not prohibit the ability for the complexed ion to
change the shape of good prions into different shaped prions.

In the Metal-Ion theory there is no good and bad prion for all prions are
equally good. The so called bad prions were victims of excess metals in the
brain and were shape changed by those metals.

Rob, can you tell me what the most common metal ions found in wild Nature
of
mosses and lichens in England where scrapie is frequent? That would be the
best place to make the one-to-one correspondence between prion variety and
metal ion specifics.

Granted my list of Cu, Fe, Al, Zn is sketchy and incorrect in spots. What I
need is an entire list of metal ions whether free or complexed found in
Nature.

And we should be able to make a matching one-to-one correspondence between
"virgin prions" and "metal deformed polluted prions". I do not know if
nickel or chromium and many other metal ions find their way into animal
brains and pose an excess problem.

Archimedes Plutonium, [Only registered users see links. ]
whole entire Universe is just one big atom where dots
of the electron-dot-cloud are galaxies

And on another level of theory.

The Prusiner Model has never offered nor provided a Thermodynamic Analysis of
how one protein that is very much alike to another protein can alter its
shape.
Usually such analysis are made before a Nobel prize is ever even considered
but in this history case of a panic in London in 1990s made the Nobel
Committee putty-headed.

Metal-ions as the root cause of all prion diseases provides that
Thermodynamical
differences in energy. Provides the energy equations. An ion is unstable from
the start and has enormous potential of energy. Contrast the difference in
potential energy between a good prion and a deformed prion. Prion to prion
action does not have the requisite energies to cause one prion to alter the
other prion.

But a collision between a prion and a metal-ion whether free metal ion or
complexed metal ion provides the required amounts of energy to alter the
shape of prion protein molecules.

Archimedes Plutonium, [Only registered users see links. ]
whole entire Universe is just one big atom where dots
of the electron-dot-cloud are galaxies

> Archimedes Plutonium, [Only registered users see links. ]

Even your tagline knows you're a wacko!!!

Get yourself a chem book *then* return to sci.chem.

Don't waste my machine time with you quasi-spam bullshit!!!


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I wonder if any chemist or biologist has been wary as I have been wary as
to the transmission of prion disease by eating the meat of infected
animals, and the brain meat especially. I mean, these alleged proteins seem
to survive inceration and intense burning and seem to survive buried. That
the Prusiner model makes these proteins as Super or Altra-proteins. The
Superman of proteins. And I have a hard time imagining that the eating of
infected meat that the Prusiner bad prions even manage to be carted past
the blood-brain barrier and deposited into the brains.

I have no trouble at visualizing the Metal Ion theory of prion disease that
metal ions survive burning and incineration and survive burial and survive
for years. And I have no trouble in visualizing the injestion of metal ions
that they easily are
transported beyond the blood-brain barrier and deposited into the brain of
the new victim.

I mean, the above is just mere commonsense that any 15 year old kid could
visualize and sense which is the better theory, the Metal-ion or the
Prusiner model.

Archimedes Plutonium, [Only registered users see links. ]
whole entire Universe is just one big atom where dots
of the electron-dot-cloud are galaxies