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-   -   where to obtain this new amphiphilic spin trap (http://www.molecularstation.com/forum/chemistry-forum/43585-where-obtain-new-amphiphilic-spin-trap.html)

matt gugan 08-18-2003 11:12 PM

where to obtain this new amphiphilic spin trap
 
anyone know where i can get this? the abstract doesnt tell us the chemical
name of this combo. if you do have the name, and it's not sold by major
companies like Sigma, TCI, etc where does one seek to have it synthesized?



Synthesis and antioxidant efficiency of a new amphiphilic spin-trap derived
from PBN and lipoic acid.

Durand G, Polidori A, Salles JP, Prost M, Durand P, Pucci B.

Laboratoire de Chimie BioOrganique et des Systemes Moleculaire Vectoriels,
Faculte des Sciences, 33 rue Louis Pasteur, 84000, Avignon, France

The synthesis of a new amphiphilic antioxidant called PBNLP and derived from
both alpha-phenyl-N-tert-butyl nitrone (PBN) and lipoic acid was described.
Grafting a lactobionamide moiety onto the aromatic group of the PBN provided
the water solubility of this compound. In vitro preliminary biological
evaluations of its antioxidant capacity were performed using the KRL
biological test based on free radical-induced hemolysis. The PBNLP induces a
protection of erythrocytes against exogenous free radicals higher than that
measured with lipoic acid or PBN alone or with lipoic acid or PBN
derivatives in admixture





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