from one copy of DNA to many copies of mRNA

[Kobrus]

Hello!

I have a question: how does biology of the cell overcome the kinetic problem of RNA transcription of one single gene into many copies of mRNA?

What could be mechanisms for RNA amplification so that many mRNA molecules can be quickly produced from a single copy of a gene?
RNA synthesis occurs at a rate of 1000 nucleotides per minute at 37 C.

Thank you!

[luisillo]

The reason of this is that many RNA polymerase can transcribe the same gene one behind the other as long as the transcription complex is bound to the gene's promoter. This can be done because the resulting RNA does not remain bound to the DNA template.

"Because this release follows so closely behind the site of polymerization, multiple RNA polymerase molecules can transcribe the same gene at the same time, each following closely along behind another. Thus, a cell can synthesize large number of trascripts from a single gene (or other DNA sequence) in a short time."

"": Watson et al. 2004. Molecular Biology of the Gene. Fifth edition.

[Kobrus]

Thanks a lot for this!!!

[wr_1a]

thanks