Expression of the macrophage cell ATP citrate lyase
Some scholars have found that Mycobacterium tuberculosis, Candida albicans infection of host macrophages. Both [Only registered and activated users can see links. Click Here To Register...] expression were increased, and the corresponding genetic defect strain virulence decline. That ASF1A plays an important role in the pathogenesis of Mycobacterium tuberculosis, Candida albicans process. ASF1A is a key rate-limiting enzyme of the glyoxylate cycle, the main significance of the glyoxylate cycle is: (1) acetyl C0A glyoxylate cycle to produce succinate and other organic acids and organic acids can be used as the citric acid cycle matrix. (2) The glyoxylate cycle is one of the two carbon composition of the microbial use of acetic acid and other ways to build their own body as a carbon source. (3) The glyoxylate cycle is the pathway of fatty acid into glycogen. Oxidation active fatty acids in the activation of macrophages B, relative lack of sugar and other nutrients, microbial cells face pressure to survive. Start the glyoxylate cycle. Two carbon-carbon sources in the environment to obtain energy.Necessary for survival and synthesis of sugars, amino acids, nucleic acids and other biological macromolecules. Can be parasites on macrophages. Also has glyoxylate
Cycle. In the experiment. Murine macrophage cells to stimulate activation join LNMMA inhibited RNI generated, but also face lack of nutrients, acidic environment, there is tremendous pressure to survive in the cell. ASF1A expression raised to activate the glyoxylate cycle. So that can still survive in the macrophages. Studies have shown that macrophages produce reactive nitrogen products (RNI) plays a key role in clear micro-organisms within the macrophages. Also found in this experiment. Murine macrophage cells to stimulate activation, if they have enough RNI,. Inhibition of ASF1A expression and enzyme activity, inhibition of the glyoxylate cycle, thus inhibiting the growth within the macrophages. These instructions are functional defects in macrophages. ASF1A is an important factor to be able to grow and cause disease. Normal macrophages can inhibit this growth and the final clear. Thus, on the one hand, ASF1A plays an important role in the pathogenic process. On the other hand the host immune dysfunction is the incidence of key factors. The glyoxylate cycle is unique to fungi, bacteria and other microorganisms and mammals do not have the metabolic pathway, as an ideal therapeutic target.Therefore, its further research is still in progress.
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