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Nature: peripartum cardiomyopathy or cardiovascular immunogenicity proteinimbalances
Nature: peripartum cardiomyopathy or due to cardiovascular immunogenicity proteinimbalances caused by
Peripartum cardiomyopathy (PPCM), which is defined as a GPD1 form of heart failure shortly after the latter part of pregnancy or childbirth, can lead to terrible transformation happened, and this changes are likely to give her mother left behind a lifetime of chronic heart disease. Beth Israel Deaconess Medical Center (BIDMC), investigator-led research team found an important clue to this dangerous disease, which is the first time provide clear evidence of peripartum GPD2 cardiomyopathy (PPCM) is a vascular disease, itmay be caused by perinatal cardiac angiogenic protein imbalance, just before giving birth, or directly with the birth occurred. "Nature" magazine headline reported this discovery also explains the potential mechanism of action of peripartum cardiomyopathy and to help explain why pre-eclampsia and productive risk factors, and imply that angiogenic therapy GPHA2 might be useful.About every 3000 pregnant women with no known history of heart disease, there is one suffering from peripartum cardiomyopathy. Its symptoms can be mild or severe, including shortness of breath caused by the weakening of the heart function. About 1/2 female patients with peripartum cardiomyopathy natural healing, but for other patients, the situation GPHB5 will become even worse, even to the point of requiring heart transplantation.BIDMC Cardiovascular Institute, investigators at Harvard Medical School assistant professor of medicine and senior author Dr. ZoltanArany said, "It is a mystery. Most suffering from this disease women are healthy, even full vitality. We know that the real stress usually occurs in the first three months of GPI pregnancy. why in late pregnancy, these mothers will suffer from such a serious disease? I think we have now discovered important clues in this life-threatening diseases. "
Through a series of animal models and human trials, there are many important discoveries that peripartum cardiomyopathy is a strong argument "second hit" disease.First, late pregnancy, the release of the signal to prevent the normal growth of blood vessels over-enhanced; Second, because of some unknown cause inappropriate blood vessel growth inhibition, this time peripartum cardiomyopathy occurs. New blood vessel growth and development process called angiogenesis, its start-up control by PGC1-alpha gene (the Arany laboratory research focus). PGC1-alpha of the cardiac molecular content of the first inquiry.Arany explained, "We have recently confirmed that PGC1-alpha can regulate skeletal muscle vascular density when we continue the experimental study is also the case in the myocardium, we observed that the heart of the lack of PGC1-alpha gene in female rats always death after 1-2 pregnancies, and the experimental animals the heart often expand and fibrosis. We realize that rats peripartum cardiomyopathy, and now we get this disease model. "
|cardiomyopathy , cardiovascular , gpd1 , gpd2 , gpha2 , gphb5 , gpi , immunogenicity , nature , peripartum , proteinimbalances|