Expression and function of ALCAM in esophageal cancer

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China is esophageal cancer morbidity and mortality in countries with the highest morbidity of malignant tumors, 4, 5-year survival of less than 10% with early esophageal cancer is highly lymph node metastasis, accounting for about 2/3 of the cases, is the main reason for poor prognosis. inhibition of lymph node metastasis is the key to effective treatment of esophageal cancer and improve survival. studies showed that tumor cells inter-Lymphatic endothelial cell migration is an important step of the process of lymph node metastasis, only detached from the primary tumor tissue, tumor cells and lymphatic endothelial cell adhesion, and across the lymphatic endothelial cell layer.

Way to migrate to lymphoid tissue, proliferate to form metastases. Cross-lymphatic endothelial migration of esophageal cancer cells for the treatment of esophageal cancer lymph node metastasis to provide new ideas.

Activation of leukocyte adhesion molecules ALCAM(activated leukocyte cell adhesion molecule) in human white blood cells and thymic epithelial cells through the same tropism and pica .Adhesion role mediated cell-cell interactions involved in the body a variety of pathophysiological process in a variety of tumor groups.The organization is highly expressed, suggesting that tumor development is closely related to adhesion and inter-endothelial function in esophageal cancer cells and lymphatic endothelial cells has not been reported to the current.The transfer is a complex process of cancer-specific, tumor cells first invasion of local tissue and through the basement membrane into the microvascular or lymphatic into the blood or lymphatic circulation, and with the target organ or tissue microvascular or lymphatic adhesion transendothelial migration, and finally into within the target organ or tissue metastases. easily with early esophageal cancer lymph node metastasis, suggesting that the interaction of esophageal cancer cells and lymphatic endothelial cells, play an important role in lymph node metastasis of esophageal cancer. ALCAM belongs to the immunoglobulin gene superfamily a member of the lymphocyte antigen CD6 ligands may be mediated by the same type of adhesion of ALCAM occurred heterophilic adhesion and can be with CD6. existing literature also reported that ALCAM high expression in a variety of tumor tissue is an independent prognostic factor for prostate cancer with breast cancer, esophageal cancer, bladder cancer prognosis.