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Cell proliferation limit and senescence

Cell proliferation limit and senescence - Biology Forum

Cell proliferation limit and senescence - Biology Forums. Ask questions and discuss the study of Biology. If you have Biology questions from your homework ask them here!


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Old 03-31-2012, 06:08 PM
Pipette Filler
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Default Cell proliferation limit and senescence



Hello,
I am trying to understand the importance of proliferation limits and cell senescence. In particular, how does the proliferation limit differ between Embryonic Stem cells (ES) and fibroblasts (which would be trans-differentiated). How does this difference plays a role when thinking about engineering organs, for example a heart transplant.

Any help? How do ES cells and fibroblasts compare with regards to the Hayflick limit?
__________
Here is what I am thinking, however I am not sure if this is correct or not.
Non-differentiated the ES cells can divide almost indefinitely, however when the stem cell differentiates into a specific function, it goes through approximately 50 cell divisions before senescence. On the other hand, fibroblasts have already gone through some cell divisions at the point when they are trans-differentiated. Therefore, their life before senescence is less than 50 cell divisions.

Can someone verify this?
Thank you.
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cell , hayflick limit , limit , proliferation , senescence , stem cell


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