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kcat/Km and kon
I need a bit of help with enzyme kinetics:
What is the reason why kcat/Km cannot be greater than kon (association rate constant)? I need a molecular or a biochemical explanation.
I found in a textbook that kcat/Km provides the lower limit for kon and that kcat/Km has an upper (higher) limit set by the diffusion rate 10^8 1/(M s); but that is not enough, I want to understand what is happening in the system and what is the meaning of the limit.
|kcat or km , kon|