Go Back   Science Forums Biology Forum Molecular Biology Forum Physics Chemistry Forum > General Science Forums > Biology Forum
Register Search Today's Posts Mark Forums Read

Biology Forum Biology Forums. Ask questions and discuss the study of Biology. If you have Biology questions from your homework ask them here!


Biological Activity of AV-951(Tivozanib)

Biological Activity of AV-951(Tivozanib) - Biology Forum

Biological Activity of AV-951(Tivozanib) - Biology Forums. Ask questions and discuss the study of Biology. If you have Biology questions from your homework ask them here!


Reply
 
LinkBack Thread Tools Display Modes
  #1  
Old 10-21-2011, 03:00 AM
Banned
Points: 58, Level: 1 Points: 58, Level: 1 Points: 58, Level: 1
Activity: 0% Activity: 0% Activity: 0%
 
Join Date: Oct 2011
Posts: 9
Thanks: 0
Thanked 0 Times in 0 Posts
Default Biological Activity of AV-951(Tivozanib)



Biological Activity of AV-951(Tivozanib):
AV-951(Tivozanib) is an orally bioavailable potent VEGFR-1, 2 and 3, cKit and PDGFR inhibitor with IC50 of 0.21, 0.16, 0.24, 1.63 and 1.72 nM, respectively.AV-951(Tivozanib) has potential antiangiogenic and antineoplastic activities[B]



AV-951(Tivozanib) inhibits c-Kit and PDGFR at 10-times higher concentrations. AV-951(Tivozanib) is a novel oral quinoline urea derivative. Preclinical data indicate that AV-951 blocks the proliferation and migration of endothelial cells in vitro, and suppresses angiogenesis and growth of human tumor xenografts in vivo. Tivozanib has been shown to be safe and orally bioavailable when given to cancer patients. AV-951(Tivozanib) is under early clinical investigation for the treatment of renal cell carcinoma and non-small cell lung carcinoma, as well as in combination with other chemotherapies in breast, colorectal, and other gastrointestinal cancer patients
Reply With Quote
Reply

Tags
activity , av-951 , av951tivozanib , biological


Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Trackbacks are On
Pingbacks are On
Refbacks are On

Forum Jump

Similar Threads
Thread Thread Starter Forum Replies Last Post
Biological Activity of PLX-4032 (RG7204, Vemurafenib, Zelboraf) kinsxu Biology Forum 1 10-10-2011 06:16 AM
Human Cytome Project - Update 24 Jan. 2005 Peter Van Osta Cell Biology and Cell Culture 1 08-01-2010 02:18 PM
Human Cytome Project - an idea - Update 19 April 2005 Peter Van Osta Cell Biology and Cell Culture 1 06-01-2009 02:17 PM
Human Cytome Project - Update 6 Jan. 2005 Peter Van Osta Cell Biology and Cell Culture 0 01-06-2005 11:18 AM
Wave Function Manipulation Experiments Consc Physics Forum 0 12-27-2004 11:07 PM


All times are GMT. The time now is 12:49 AM.


Powered by vBulletin® Version 3.8.4
Copyright ©2000 - 2014, Jelsoft Enterprises Ltd.
Copyright 2005 - 2012 Molecular Station | All Rights Reserved
Page generated in 0.15593 seconds with 16 queries