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cell permeability of huge sized compounds

cell permeability of huge sized compounds - Biology Forum

cell permeability of huge sized compounds - Biology Forums. Ask questions and discuss the study of Biology. If you have Biology questions from your homework ask them here!


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  #1  
Old 12-05-2010, 06:37 PM
Pipette Filler
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Default cell permeability of huge sized compounds



Dear All,

I am intrigued by a basic question of late... I have a chemical compound with a molecular weight of 1700Da and what i want to know from any of you is that, is there a possibility for such a huge compound to enter any human cell in culture through its membrane. By the way the compound is highly and easily soluble in water!

I am beginning this work only now and have no prior expertise regarding this. A help from any of you is much much much needed to further my work.

Please do help with your views.

Kind Regards,

Vinod.
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Old 12-06-2010, 05:21 PM
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Default Re: cell permeability of huge sized compounds

High weight/size compounds usually have membrane transports for it movement. Whether they have passive or active movement, as far as I know, there are always specific transporters for them in cell membranes.

If your compound doesn't have a specific transporter in the membrane, I doubt it'd be able to get inside the cell, unless you use micels or something like that
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  #3  
Old 12-07-2010, 09:54 AM
Pipette Filler
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Default Re: cell permeability of huge sized compounds

Hi SebaQ,

Thank you very much for your reply. I am planning to do some permeability assays with my compound. I guess that should be conclusive.

Thanks again.

Vinod.
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