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SNPs and Chromosomes

SNPs and Chromosomes - Biology Forum

SNPs and Chromosomes - Biology Forums. Ask questions and discuss the study of Biology. If you have Biology questions from your homework ask them here!


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Old 03-09-2009, 01:10 AM
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Question SNPs and Chromosomes



Hi.

I would like to know how companies decide which of the two copies of each chromosome (maternal vs paternal) they will use in order to identify / genotype SNPs

Thanks

Sam
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Old 03-18-2009, 01:07 AM
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Default Re: SNPs and Chromosomes

To give you your genotype, they take all your DNA and run SNP PCRs on it. They can track the inheritiance of the SNP to either mom or dad, only when mom and dad DNA samples are also available.

In the case of rape kits, DAD dna can be isolated by washing excess DNA (mom contamination) off the sperm--then using detergent to break up the S-S bonds in the sperm and thus only getting DAD's DNA.
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