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02-20-2007, 08:59 AM
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 Drug design help We have identified a Leishmania (parasite) protein disulfide isomerase (LmPDI) that play a key role in parasite pathogenicity. As PDIs, this protein contains two active sites (CGHC) and display an enzymatic activity. In addition, this activity is blocked by classic PDIs inhibitors (Bacitracin, pCMBS…). Recently, we have shown that parasites KO deleted from lmpdi gene are viable in vitro however are avirulent in the experimental mouse model. These results strongly suggest that LmPDI may constitutes a promising drug target. Unfortunately, I’m not a specialist in drug design (I'm a molecular biologist ) and Is someone have an idea about teams or pharmaceutical groups with a strong experience that could be interested on anti-LmPDI drug discovery . Thank you        |
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