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The serotonin signalling pathway causes C.elegans worms to slow down. A genetic screen identifies 3 genes that are required for serotonin-induced slowing. The first encodes the alpha subunit of a heterotrimeric G protein - Gq alpha. The second encodes a serine/threonine kinase, PKC. The third encodes a novel protein that shares no obvious homologies with proteins of known function.
Describe experiments that would define;
1.Whether these genes act within the same cells to mediate serotonin slowing response.
2.The order in which these genes are activated in the serotonin slowing pathway.
3.The function of the third gene.
|cell , signalling|
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