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2 Questions on Biochemistry Homework

2 Questions on Biochemistry Homework - Biochemistry Forum

2 Questions on Biochemistry Homework - Discuss and post questions regarding the study of Biochemistry. If you need homework help this is the place to ask!


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Old 10-03-2011, 01:37 AM
Pipette Filler
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Default 2 Questions on Biochemistry Homework



Oxygen binds to a myoglobin with a Kd of 3.68 x 10-3atm.?

Question 1: At what concentration of oxygen will θ be 0.2? Show all work.

Question 2: What is Ka? I think I have this correct, is it 1/Kd.

Question 3: Does oxygen bind more tightly or less tightly than carbon monoxide (Kd of 6.13 x 10-5 atm)?


The hemoglobin variant named Hb Bassett involves the mutation of an aspartate in the alpha subunit into an alanine. Structural studies show that this mutation is in the interface between the alpha and beta subunit of the protein. This mutation destabilizes the R state (through disruption of a hydrogen bond between the subunits) relative to the T state.

What effect would this mutation have on the binding affinity of this hemoglobin variant for oxygen, relative to wild-type hemoglobin? Why?

What effect does this have on its ability to pick up oxygen in the lungs and deliver it to working muscles and other peripheral tissues? Why/how? Please be detailed in your answer.

How serious do you think this mutation would be for the survival of a human?

This is a homework question for biochemistry so if you do not want to give me the answer can you help lead me to the answer?

Thanks,
Justin
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