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Glycerol to Glucose

Glycerol to Glucose - Biochemistry Forum

Glycerol to Glucose - Discuss and post questions regarding the study of Biochemistry. If you need homework help this is the place to ask!


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Old 04-09-2011, 05:03 PM
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Default Glycerol to Glucose



Hi,

There are some situations in which the body converts fat to sugar,
and uses the glycerol molecule for that purpose.

Does anyone know how many glucose molecules are a product of one glycerol molecule?
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Old 04-03-2014, 03:23 PM
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Default Re: Glycerol to Glucose

The contribution of glycerol to glucose production has been measured in healthy volunteers by the simultaneous primed constant infusion of 1-[13C]glycerol and 3-[3H]glucose and the determination of the rates of appearance (Ra) of glycerol, glucose, and glycerol-derived glucose. In the postabsorptive state, glycerol Ra was 3.11 +/- 0.44 mumol.kg-1.min-1, of which 36% was converted to glucose, accounting for 4.5% of total glucose production. After 62-86 h of starvation, glycerol Ra rose to 5.32 +/- 0.58 mumol.kg-1.min-1, and 68% of glycerol was converted to glucose. This accounted for 21.6% of total glucose production. Glycerol Ra was closely correlated with its conversion and contribution to glucose. These findings confirm that the contribution of glycerol to glucose production is directly correlated to its release as a consequence of lipolysis and support the notion that the central physiological role of accelerated lipolysis in fasting is the provision of gluconeogenic precursor.
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