Islet Inflammation in Autoimmune Diabetes - Type 1 Diabetes Breakthrough
Canada does it again in Diabetes Research!
The team of researchers from Canada discovered that abnormal nerve endings in the insulin-producing cells of the pancreas initiated a chain of events that caused Type 1 diabetes in mice. The removal of these nerve cells blocked the mice from developing Type 1 Diabetes.
Dr. Dosch, a researcher at Sick Children's Hospital et al. identified a control circuit between islet cells and their related sensory nerves. The disruption of this circuit led to inflammation around the islets and eventually to their destruction. Without these cells, the mice could not make insulin.
The article was published yesterday in the Journal Cell
To read the full Article see: [Only registered users see links. ]
Cell 2006 127: 1123-1135