Hey, I am working on a coursework and I was hoping someone could help me out on the following questions. Any hints on how to approach these problems is appreciated (or literature to read...etc).
A. During fasting body protein is mobilised to make glucose to maintain blood glucose levels for the central nervous system. Amino acids are deaminated and the carbon skeletons used to make glucose in the process of gluconeogenesis. Similarly during times of adequate diet amino acids are deaminated and may be used in respiration.
• In starvation, when amino acids are being used for gluconeogenesis, if the glutamate were radiolabelled with 14C at C4 (γ carbon), which carbon(s), if any, in glucose would become radiolabelled?
B. Radiolabelled carbon from acetyl-CoA can become incorporated into glucose even though carbohydrate cannot be made nett from fatty acids. Explain how this can be so.