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question about mutagenesis

question about mutagenesis - Biochemistry Forum

question about mutagenesis - Discuss and post questions regarding the study of Biochemistry. If you need homework help this is the place to ask!


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Old 03-30-2009, 10:59 PM
Pipette Filler
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Default question about mutagenesis



Hi guys, I am wondering what could be the best a.a. substitution for glycine? Under what circumstances could you make this substitution without disrupting the structure of the protein? (Assume you could look at a crystal structure). If you did not have a crystal structure, how could you predict whether substitution for glycine might be tolerated? If tolerated, a substitution for glycine by other amino acids can increase thermal stability of proteins. Why might this be so? I can think of two reasons, one an effect on the folded state and one an effect on the unfolded state.
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