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TCA Thermodynamics: calculating ΔG

TCA Thermodynamics: calculating ΔG - Biochemistry Forum

TCA Thermodynamics: calculating ΔG - Discuss and post questions regarding the study of Biochemistry. If you need homework help this is the place to ask!

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Old 02-22-2009, 03:14 PM
Pipette Filler
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Default TCA Thermodynamics: calculating ΔG

Citrate is formed in an exergonic condensation reaction (ΔG' = -32.2 kJ/mol) catalyzed by citrate synthase. Imagine your cellular concentrations of reactants and products are the following:

oxaloacetate 1 μm;
Acetyl CoA 1 μm;
Citrate 400 μm;
CoA 70 μm.

Calculating ΔG for this condition, in which direction does the reaction
proceed? If the concentration of all other compounds remained the same, which theoretical concentration of citrate would halt the reaction?
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