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JBC Journal of Biological Chemistry [Archive] - Molecular Biology Forum
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  1. [Minireviews] Hyaluronan Synthases: A Decade-plus of Novel Glycosyltransferases
  2. [Membrane Transport, Structure, Function, and Biogenesis] Novel Conantokins from Conus parius Venom Are Specific Antagonists of N-Methyl-D-aspartate Receptors
  3. [Metabolism and Bioenergetics] Characterization of the NuoM (ND4) Subunit in Escherichia coli NDH-1: CONSERVED CHARGED RESIDUES ESSENTIAL FOR ENERGY-COUPLED ACTIVITIES
  4. [Protein Structure and Folding] Gp120 V3-dependent Impairment of R5 HIV-1 Infectivity Due to Virion-incorporated CCR5
  5. [Glycobiology and Extracellular Matrices] Fragmentation of Proteins in Cartilage Treated with Interleukin-1: SPECIFIC CLEAVAGE OF TYPE IX COLLAGEN BY MATRIX METALLOPROTEINASE 13 RELEASES THE NC4 DOMAIN
  6. [Enzyme Catalysis and Regulation] The M.EcoRV DNA-(Adenine N6)-methyltransferase Uses DNA Bending for Recognition of an Expanded EcoDam Recognition Site
  7. [Mechanisms Of Signal Transduction] Signaling by Toll-like Receptors 8 and 9 Requires Bruton's Tyrosine Kinase
  8. [Protein Structure and Folding] Three-dimensional Reconstruction Using Transmission Electron Microscopy Reveals a Swollen, Bell-shaped Structure of Transient Receptor Potential Melastatin Type 2 Cation Channel
  9. [Protein Synthesis, Post-Translational Modification, and Degradation] Arrestin-2 Interacts with the Ubiquitin-Protein Isopeptide Ligase Atrophin-interacting Protein 4 and Mediates Endosomal Sorting of the Chemokine Receptor CXCR4
  10. [Enzyme Catalysis and Regulation] DNA Accelerates the Inhibition of Human Cathepsin V by Serpins
  11. [Protein Structure and Folding] Site-specific Effects of Peptide Lipidation on -Amyloid Aggregation and Cytotoxicity
  12. [Protein Synthesis, Post-Translational Modification, and Degradation] Functional Interactions between the G' Subdomain of Bacterial Translation Factor EF-G and Ribosomal Protein L7/L12
  13. [Glycobiology and Extracellular Matrices] Chondroitinase-mediated Degradation of Rare 3-O-Sulfated Glucuronic Acid in Functional Oversulfated Chondroitin Sulfate K and E
  14. [Mechanisms Of Signal Transduction] Induction of a Group 2 {sigma} Factor, RPOD3, by High Light and the Underlying Mechanism in Synechococcus elongatus PCC 7942
  15. [Mechanisms Of Signal Transduction] Dissecting the Facilitator and Inhibitor Allosteric Metal Sites of the P2X4 Receptor Channel: CRITICAL ROLES OF CYS132 FOR ZINC POTENTIATION AND ASP138 FOR COPPER INHIBITION
  16. [Metabolism and Bioenergetics] Detection of Reactive Oxygen Species via Endogenous Oxidative Pentose Phosphate Cycle Activity in Response to Oxygen Concentration: IMPLICATIONS FOR THE MECHANISM OF HIF-1{alpha} STABILIZATION UNDER MODERATE HYPOXIA
  17. [Protein Synthesis, Post-Translational Modification, and Degradation] Functional Analysis of the Interplay between Translation Termination, Selenocysteine Codon Context, and Selenocysteine Insertion Sequence-binding Protein 2
  18. [Protein Synthesis, Post-Translational Modification, and Degradation] Major House Dust Mite Allergens Dermatophagoides pteronyssinus 1 and Dermatophagoides farinae 1 Degrade and Inactivate Lung Surfactant Proteins A and D
  19. [Protein Synthesis, Post-Translational Modification, and Degradation] Identification of in Vivo Phosphorylation Sites and Their Functional Significance in the Sodium Iodide Symporter
  20. [Enzyme Catalysis and Regulation] Signal Peptide Peptidase and {gamma}-Secretase Share Equivalent Inhibitor Binding Pharmacology
  21. [Transcription, Chromatin, and Epigenetics] Negative Regulation of Inducible Nitric-oxide Synthase Expression Mediated through Transforming Growth Factor- -dependent Modulation of Transcription Factor TCF11
  22. [Metabolism and Bioenergetics] A Point Mutation in atpC1 Raises the Redox Potential of the Arabidopsis Chloroplast ATP Synthase {gamma}-Subunit Regulatory Disulfide above the Range of Thioredoxin Modulation
  23. [Metabolism and Bioenergetics] Mitochondrial ND5 Gene Variation Associated with Encephalomyopathy and Mitochondrial ATP Consumption
  24. [Membrane Transport, Structure, Function, and Biogenesis] Lysophosphatidylcholine Metabolism in Saccharomyces cerevisiae: THE ROLE OF P-TYPE ATPases IN TRANSPORT AND A BROAD SPECIFICITY ACYLTRANSFERASE IN ACYLATION
  25. [Molecular Basis Of Cell and Developmental Biology] HFE Modulates Transferrin Receptor 2 Levels in Hepatoma Cells via Interactions That Differ from Transferrin Receptor 1-HFE Interactions
  26. [Molecular Basis Of Cell and Developmental Biology] Interaction of the DYNLT (TCTEX1/RP3) Light Chains and the Intermediate Chains Reveals Novel Intersubunit Regulation during Assembly of the Dynein Complex
  27. [Mechanisms Of Signal Transduction] Peroxisome Proliferator-activated Receptor {gamma} Up-regulates the Bcl-2 Anti-apoptotic Protein in Neurons and Induces Mitochondrial Stabilization and Protection against Oxidative Stress and Apoptosis
  28. [Metabolism and Bioenergetics] Evidence for nifU and nifS Participation in the Biosynthesis of the Iron-Molybdenum Cofactor of Nitrogenase
  29. [Lipids and Lipoproteins] The Cellular Functions of the Yeast Lipin Homolog Pah1p Are Dependent on Its Phosphatidate Phosphatase Activity
  30. [Dna: Replication, Repair, Recombination, and Chromosome Dynamics] Saccharomyces cerevisiae MutL{alpha} Is a Mismatch Repair Endonuclease
  31. [Protein Structure and Folding] Crystal Structure of the Interleukin-15{middle dot}Interleukin-15 Receptor {alpha} Complex: INSIGHTS INTO TRANS AND CIS PRESENTATION
  32. [Membrane Transport, Structure, Function, and Biogenesis] Controlling the Inhibition of the Sarcoplasmic Ca2+-ATPase by Tuning Phospholamban Structural Dynamics
  33. [Mechanisms Of Signal Transduction] Binding of Rac1, Rnd1, and RhoD to a Novel Rho GTPase Interaction Motif Destabilizes Dimerization of the Plexin-B1 Effector Domain
  34. [Mechanisms Of Signal Transduction] Abnormal Taste Perception in Mice Lacking the Type 3 Inositol 1,4,5-Trisphosphate Receptor
  35. [Mechanisms Of Signal Transduction] Modulation of F-actin Rearrangement by the Cyclic AMP/cAMP-dependent Protein Kinase (PKA) Pathway Is Mediated by MAPK-activated Protein Kinase 5 and Requires PKA-induced Nuclear Export of MK5
  36. [Mechanisms Of Signal Transduction] Control of Phenotypic Plasticity of Smooth Muscle Cells by Bone Morphogenetic Protein Signaling through the Myocardin-related Transcription Factors
  37. [Enzyme Catalysis and Regulation] Acetyl-lysine Analog Peptides as Mechanistic Probes of Protein Deacetylases
  38. [Membrane Transport, Structure, Function, and Biogenesis] Precursor Protein Is Readily Degraded in Mitochondrial Matrix Space if the Leader Is Not Processed by Mitochondrial Processing Peptidase
  39. [Protein Synthesis, Post-Translational Modification, and Degradation] BAG-1 Associates with Hsc70{middle dot}Tau Complex and Regulates the Proteasomal Degradation of Tau Protein
  40. [Molecular Basis Of Cell and Developmental Biology] Heat Shock Transcription Factor 1 Is Required for Maintenance of Ciliary Beating in Mice
  41. [Papers Of The Week] ATP Synthase Activation and Photosynthesis
  42. [Mechanisms Of Signal Transduction] Bone Morphogenetic Protein 2 Opposes Shh-mediated Proliferation in Cerebellar Granule Cells through a TIEG-1-based Regulation of Nmyc
  43. [Protein Structure and Folding] The Lipid Droplet Binding Domain of Hepatitis C Virus Core Protein Is a Major Determinant for Efficient Virus Assembly
  44. [Protein Structure and Folding] Solution Structure of Selenoprotein W and NMR Analysis of Its Interaction with 14-3-3 Proteins
  45. [Protein Synthesis, Post-Translational Modification, and Degradation] Cell Type-specific Functions of the Lysosomal Protease Cathepsin L in the Heart
  46. [Molecular Basis Of Cell and Developmental Biology] Znt7 (Slc30a7)-deficient Mice Display Reduced Body Zinc Status and Body Fat Accumulation
  47. [Mechanisms Of Signal Transduction] Calcineurin Promotes Hypoxia-inducible Factor 1{alpha} Expression by Dephosphorylating RACK1 and Blocking RACK1 Dimerization
  48. [Enzyme Catalysis and Regulation] Asparatic Acid 221 Is Critical in the Calcium-induced Modulation of the Enzymatic Activity of Human Aminopeptidase A
  49. [Lipids and Lipoproteins] Hypermethylation of Fads2 and Altered Hepatic Fatty Acid and Phospholipid Metabolism in Mice with Hyperhomocysteinemia
  50. [Mechanisms Of Signal Transduction] The Functional Role of an Interleukin 6-inducible CDK9{middle dot}STAT3 Complex in Human {gamma}-Fibrinogen Gene Expression
  51. [Transcription, Chromatin, and Epigenetics] I{kappa}B-{alpha} Represses the Transcriptional Activity of the HIV-1 Tat Transactivator by Promoting Its Nuclear Export
  52. [Protein Structure and Folding] A Novel Structural Fold in Polysaccharide Lyases: BACILLUS SUBTILIS FAMILY 11 RHAMNOGALACTURONAN LYASE YesW WITH AN EIGHT-BLADED -PROPELLER
  53. [Molecular Basis Of Cell and Developmental Biology] The Pancreatitis-induced Vacuole Membrane Protein 1 Triggers Autophagy in Mammalian Cells
  54. [Protein Structure and Folding] The Active Site of an Algal Prolyl 4-Hydroxylase Has a Large Structural Plasticity
  55. [Protein Structure and Folding] Crystal Structures of Blasticidin S Deaminase (BSD): IMPLICATIONS FOR DYNAMIC PROPERTIES OF CATALYTIC ZINC
  56. [Protein Synthesis, Post-Translational Modification, and Degradation] OS-9 Regulates the Transit and Polyubiquitination of TRPV4 in the Endoplasmic Reticulum
  57. [Papers Of The Week] Salmonella: Killing Macrophages via Glycolysis Enzymes
  58. [Molecular Basis Of Cell and Developmental Biology] Induction of Nuclear Translocation of Constitutive Androstane Receptor by Peroxisome Proliferator-activated Receptor {alpha} Synthetic Ligands in Mouse Liver
  59. [Molecular Basis Of Cell and Developmental Biology] Activin Regulates Estrogen Receptor Gene Expression in the Mouse Ovary
  60. [Mechanisms Of Signal Transduction] Ebp1 Association with Nucleophosmin/B23 Is Essential for Regulating Cell Proliferation and Suppressing Apoptosis
  61. [Protein Structure and Folding] In-cell Aggregation of a Polyglutamine-containing Chimera Is a Multistep Process Initiated by the Flanking Sequence
  62. [Protein Structure and Folding] Resistance to Neutralization by Antibodies Targeting the Coiled Coil of Fusion-active Envelope Is a Common Feature of Retroviruses
  63. [Protein Synthesis, Post-Translational Modification, and Degradation] Autosomal Ichthyosis with Hypotrichosis Syndrome Displays Low Matriptase Proteolytic Activity and Is Phenocopied in ST14 Hypomorphic Mice
  64. [Transcription, Chromatin, and Epigenetics] The Human Monocytic Leukemia Zinc Finger Histone Acetyltransferase Domain Contains DNA-binding Activity Implicated in Chromatin Targeting
  65. [Glycobiology and Extracellular Matrices] Expression of Bisecting Type and Lewisx/Lewisy Terminated N-Glycans on Human Sperm
  66. [Transcription, Chromatin, and Epigenetics] A Tunable Ratchet Driving Human RNA Polymerase II Translocation Adjusted by Accurately Templated Nucleoside Triphosphates Loaded at Downstream Sites and by Elongation Factors
  67. [Mechanisms Of Signal Transduction] Connective Tissue Growth Factor Is Overexpressed in Esophageal Squamous Cell Carcinoma and Promotes Tumorigenicity through -Catenin-T-cell Factor/Lef Signaling
  68. [Protein Structure and Folding] Crystal Structure of the Non-heme Iron Dioxygenase PtlH in Pentalenolactone Biosynthesis
  69. [Metabolism and Bioenergetics] Regulation of Iron Homeostasis Mediated by the Heme-binding Protein Dap1 (Damage Resistance Protein 1) via the P450 Protein Erg11/Cyp51
  70. [Membrane Transport, Structure, Function, and Biogenesis] Phosphatidylinositol 4-Phosphate 5-Kinase Reduces Cell Surface Expression of the Epithelial Sodium Channel (ENaC) in Cultured Collecting Duct Cells
  71. [Protein Synthesis, Post-Translational Modification, and Degradation] Hemin Interactions and Alterations of the Subcellular Localization of Prion Protein
  72. [Protein Structure and Folding] Isolating the Epstein-Barr Virus gp350/220 Binding Site on Complement Receptor Type 2 (CR2/CD21)
  73. [Protein Structure and Folding] The Crystal Structure of D7r4, a Salivary Biogenic Amine-binding Protein from the Malaria Mosquito Anopheles gambiae
  74. [Protein Structure and Folding] Highly Promiscuous Nature of Prion Polymerization
  75. [Membrane Transport, Structure, Function, and Biogenesis] Role of TASK2 in the Control of Apoptotic Volume Decrease in Proximal Kidney Cells
  76. [Membrane Transport, Structure, Function, and Biogenesis] Clustering of Membrane Raft Proteins by the Actin Cytoskeleton
  77. [Protein Synthesis, Post-Translational Modification, and Degradation] A Suppressive Role of the Prolyl Isomerase Pin1 in Cellular Apoptosis Mediated by the Death-associated Protein Daxx
  78. [Lipids and Lipoproteins] Tuning of the Outer Hair Cell Motor by Membrane Cholesterol
  79. [Protein Structure and Folding] DyP, a Unique Dye-decolorizing Peroxidase, Represents a Novel Heme Peroxidase Family: ASP171 REPLACES THE DISTAL HISTIDINE OF CLASSICAL PEROXIDASES
  80. [Metabolism and Bioenergetics] A Role for the Transcriptional Coactivator PGC-1{alpha} in Muscle Refueling
  81. [Mechanisms Of Signal Transduction] Live-cell Molecular Analysis of Akt Activation Reveals Roles for Activation Loop Phosphorylation
  82. [Lipids and Lipoproteins] Transfer of Monomeric Endotoxin from MD-2 to CD14: CHARACTERIZATION AND FUNCTIONAL CONSEQUENCES
  83. [Metabolism and Bioenergetics] Metabolism and Elimination of the Endogenous DNA Adduct, 3-(2-Deoxy- -D-erythropentofuranosyl)-pyrimido[1,2-{alpha}]purine-10(3H)-one, in the Rat
  84. [Rna: Processing and Catalysis] Heterogeneous Ribonucleoprotein M Is a Splicing Regulatory Protein That Can Enhance or Silence Splicing of Alternatively Spliced Exons
  85. [Metabolism and Bioenergetics] Intake of Sucrose-sweetened Water Induces Insulin Resistance and Exacerbates Memory Deficits and Amyloidosis in a Transgenic Mouse Model of Alzheimer Disease
  86. [Protein Synthesis, Post-Translational Modification, and Degradation] Proteolysis of the Membrane Type-1 Matrix Metalloproteinase Prodomain: IMPLICATIONS FOR A TWO-STEP PROTEOLYTIC PROCESSING AND ACTIVATION
  87. [Mechanisms Of Signal Transduction] Identification of a Calmodulin-binding NAC Protein as a Transcriptional Repressor in Arabidopsis
  88. [Membrane Transport, Structure, Function, and Biogenesis] Differential Activities of Glucocorticoid-induced Leucine Zipper Protein Isoforms
  89. [Protein Structure and Folding] Selection of Genetically Encoded Fluorescent Single Domain Antibodies Engineered for Efficient Expression in Escherichia coli
  90. [Transcription, Chromatin, and Epigenetics] Runx2- and Histone Deacetylase 3-mediated Repression Is Relieved in Differentiating Human Osteoblast Cells to Allow High Bone Sialoprotein Expression
  91. [Mechanisms Of Signal Transduction] Critical Role of the Phosphatidylinositol 3-Kinase/Akt/Glycogen Synthase Kinase-3 Signaling Pathway in Recovery from Anthrax Lethal Toxin-induced Cell Cycle Arrest and MEK Cleavage in Macrophages
  92. [Mechanisms Of Signal Transduction] NOD2 Pathway Activation by MDP or Mycobacterium tuberculosis Infection Involves the Stable Polyubiquitination of Rip2
  93. [Dna: Replication, Repair, Recombination, and Chromosome Dynamics] Metal-catalyzed Oxidation of the Werner Syndrome Protein Causes Loss of Catalytic Activities and Impaired Protein-Protein Interactions
  94. [Transcription, Chromatin, and Epigenetics] Sumoylation-dependent Control of Homotypic and Heterotypic Synergy by the Kruppel-type Zinc Finger Protein ZBP-89
  95. [Membrane Transport, Structure, Function, and Biogenesis] The Leader Peptide of Yeast Atp6p Is Required for Efficient Interaction with the Atp9p Ring of the Mitochondrial ATPase
  96. [Mechanisms Of Signal Transduction] Role for KAP1 Serine 824 Phosphorylation and Sumoylation/Desumoylation Switch in Regulating KAP1-mediated Transcriptional Repression
  97. [Mechanisms Of Signal Transduction] NRAMP-1 Expression Modulates Protein-tyrosine Phosphatase Activity in Macrophages: IMPACT ON HOST CELL SIGNALING AND FUNCTIONS
  98. [Mechanisms Of Signal Transduction] Regulation of Peroxiredoxins by Nitric Oxide in Immunostimulated Macrophages
  99. [Membrane Transport, Structure, Function, and Biogenesis] Twin Arginine Translocation (Tat)-dependent Export in the Apparent Absence of TatABC or TatA Complexes Using Modified Escherichia coli TatA Subunits That Substitute for TatB
  100. [Mechanisms Of Signal Transduction] NHERF1 Regulates Parathyroid Hormone Receptor Membrane Retention without Affecting Recycling
  101. [Mechanisms Of Signal Transduction] The Caspase-1 Digestome Identifies the Glycolysis Pathway as a Target during Infection and Septic Shock
  102. [Mechanisms Of Signal Transduction] Hypoxia-inducible Factor-1 Mediates Neuronal Expression of the Receptor for Advanced Glycation End Products following Hypoxia/Ischemia
  103. [Protein Synthesis, Post-Translational Modification, and Degradation] Regulation of Protein Arginine Methyltransferase 8 (PRMT8) Activity by Its N-terminal Domain
  104. [Molecular Basis Of Cell and Developmental Biology] Osteocrin Is a Specific Ligand of the Natriuretic Peptide Clearance Receptor That Modulates Bone Growth
  105. [Mechanisms Of Signal Transduction] Shp2E76K Mutant Confers Cytokine-independent Survival of TF-1 Myeloid Cells by Up-regulating Bcl-XL
  106. [Mechanisms Of Signal Transduction] The Role of the N Terminus and Transmembrane Domain of TRPM8 in Channel Localization and Tetramerization
  107. [Membrane Transport, Structure, Function, and Biogenesis] Molecular Proximity of Cystic Fibrosis Transmembrane Conductance Regulator and Epithelial Sodium Channel Assessed by Fluorescence Resonance Energy Transfer
  108. [Protein Structure and Folding] Stabilization of an Immunoglobulin Fold Domain by an Engineered Disulfide Bond at the Buried Hydrophobic Region
  109. [Enzyme Catalysis and Regulation] A Novel Calmodulin-Ca2+ Target Recognition Activates the Bcl-2 Regulator FKBP38
  110. [Protein Structure and Folding] Three-dimensional Structure of the EphB2 Receptor in Complex with an Antagonistic Peptide Reveals a Novel Mode of Inhibition
  111. [Dna: Replication, Repair, Recombination, and Chromosome Dynamics] Structure and Activity of Y-class DNA Polymerase DPO4 from Sulfolobus solfataricus with Templates Containing the Hydrophobic Thymine Analog 2,4-Difluorotoluene
  112. [Mechanisms Of Signal Transduction] An Auto-regulatory Loop between Stress Sensors INrf2 and Nrf2 Controls Their Cellular Abundance
  113. [Membrane Transport, Structure, Function, and Biogenesis] TBC1D20 Is a Rab1 GTPase-activating Protein That Mediates Hepatitis C Virus Replication
  114. [Mechanisms Of Signal Transduction] Down-regulation of Phosphoglucose Isomerase/Autocrine Motility Factor Expression Sensitizes Human Fibrosarcoma Cells to Oxidative Stress Leading to Cellular Senescence
  115. [Molecular Basis Of Cell and Developmental Biology] Spatiotemporal Expression of Ameloblastin Isoforms during Murine Tooth Development
  116. [Enzyme Catalysis and Regulation] The Molecular Basis for Inhibition of BphD, a C-C Bond Hydrolase Involved in Polychlorinated Biphenyls Degradation: LARGE 3-SUBSTITUENTS PREVENT TAUTOMERIZATION
  117. [Transcription, Chromatin, and Epigenetics] Daxx-like Protein of Drosophila Interacts with Dmp53 and Affects Longevity and Ark mRNA Level
  118. [Enzyme Catalysis and Regulation] The Essential Cell Division Protein FtsN Interacts with the Murein (Peptidoglycan) Synthase PBP1B in Escherichia coli
  119. [Protein Structure and Folding] Selective Incorporation of Polyanionic Molecules into Hamster Prions
  120. [Enzyme Catalysis and Regulation] Identification of Aspartic Acid and Histidine Residues Mediating the Reaction Mechanism and the Substrate Specificity of the Human UDP-glucuronosyltransferases 1A
  121. [Classics] The Conversion of Phenylalanine to Tyrosine: the Work of Seymour Kaufman
  122. [Accelerated Publications] Gain-of-function Mutation in TRPML3 Causes the Mouse Varitint-Waddler Phenotype
  123. [Minireviews] Actin Structure and Function: What We Still Do Not Understand