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- [Metabolism and Bioenergetics] Characterization of the NuoM (ND4) Subunit in Escherichia coli NDH-1: CONSERVED CHARGED RESIDUES ESSENTIAL FOR ENERGY-COUPLED ACTIVITIES
- [Mechanisms Of Signal Transduction] Peroxisome Proliferator-activated Receptor {gamma} Up-regulates the Bcl-2 Anti-apoptotic Protein in Neurons and Induces Mitochondrial Stabilization and Protection against Oxidative Stress and Apoptosis
- [Protein Structure and Folding] Gp120 V3-dependent Impairment of R5 HIV-1 Infectivity Due to Virion-incorporated CCR5
- [Glycobiology and Extracellular Matrices] Fragmentation of Proteins in Cartilage Treated with Interleukin-1: SPECIFIC CLEAVAGE OF TYPE IX COLLAGEN BY MATRIX METALLOPROTEINASE 13 RELEASES THE NC4 DOMAIN
- [Molecular Basis Of Cell and Developmental Biology] Interaction of the DYNLT (TCTEX1/RP3) Light Chains and the Intermediate Chains Reveals Novel Intersubunit Regulation during Assembly of the Dynein Complex
- [Enzyme Catalysis and Regulation] The M.EcoRV DNA-(Adenine N6)-methyltransferase Uses DNA Bending for Recognition of an Expanded EcoDam Recognition Site
- [Mechanisms Of Signal Transduction] Signaling by Toll-like Receptors 8 and 9 Requires Bruton's Tyrosine Kinase
- [Protein Structure and Folding] Three-dimensional Reconstruction Using Transmission Electron Microscopy Reveals a Swollen, Bell-shaped Structure of Transient Receptor Potential Melastatin Type 2 Cation Channel
- [Protein Synthesis, Post-Translational Modification, and Degradation] Arrestin-2 Interacts with the Ubiquitin-Protein Isopeptide Ligase Atrophin-interacting Protein 4 and Mediates Endosomal Sorting of the Chemokine Receptor CXCR4
- [Enzyme Catalysis and Regulation] DNA Accelerates the Inhibition of Human Cathepsin V by Serpins
- [Protein Structure and Folding] Site-specific Effects of Peptide Lipidation on -Amyloid Aggregation and Cytotoxicity
- [Protein Synthesis, Post-Translational Modification, and Degradation] Functional Interactions between the G' Subdomain of Bacterial Translation Factor EF-G and Ribosomal Protein L7/L12
- [Membrane Transport, Structure, Function, and Biogenesis] Novel Conantokins from Conus parius Venom Are Specific Antagonists of N-Methyl-D-aspartate Receptors
- [Glycobiology and Extracellular Matrices] Chondroitinase-mediated Degradation of Rare 3-O-Sulfated Glucuronic Acid in Functional Oversulfated Chondroitin Sulfate K and E
- [Mechanisms Of Signal Transduction] Induction of a Group 2 {sigma} Factor, RPOD3, by High Light and the Underlying Mechanism in Synechococcus elongatus PCC 7942
- [Minireviews] Hyaluronan Synthases: A Decade-plus of Novel Glycosyltransferases
- [Protein Synthesis, Post-Translational Modification, and Degradation] Identification of in Vivo Phosphorylation Sites and Their Functional Significance in the Sodium Iodide Symporter
- [Metabolism and Bioenergetics] Detection of Reactive Oxygen Species via Endogenous Oxidative Pentose Phosphate Cycle Activity in Response to Oxygen Concentration: IMPLICATIONS FOR THE MECHANISM OF HIF-1{alpha} STABILIZATION UNDER MODERATE HYPOXIA
- [Protein Synthesis, Post-Translational Modification, and Degradation] Functional Analysis of the Interplay between Translation Termination, Selenocysteine Codon Context, and Selenocysteine Insertion Sequence-binding Protein 2
- [Protein Synthesis, Post-Translational Modification, and Degradation] Major House Dust Mite Allergens Dermatophagoides pteronyssinus 1 and Dermatophagoides farinae 1 Degrade and Inactivate Lung Surfactant Proteins A and D
- [Enzyme Catalysis and Regulation] Signal Peptide Peptidase and {gamma}-Secretase Share Equivalent Inhibitor Binding Pharmacology
- [Transcription, Chromatin, and Epigenetics] Negative Regulation of Inducible Nitric-oxide Synthase Expression Mediated through Transforming Growth Factor- -dependent Modulation of Transcription Factor TCF11
- [Metabolism and Bioenergetics] Mitochondrial ND5 Gene Variation Associated with Encephalomyopathy and Mitochondrial ATP Consumption
- [Membrane Transport, Structure, Function, and Biogenesis] Lysophosphatidylcholine Metabolism in Saccharomyces cerevisiae: THE ROLE OF P-TYPE ATPases IN TRANSPORT AND A BROAD SPECIFICITY ACYLTRANSFERASE IN ACYLATION
- [Molecular Basis Of Cell and Developmental Biology] HFE Modulates Transferrin Receptor 2 Levels in Hepatoma Cells via Interactions That Differ from Transferrin Receptor 1-HFE Interactions
- [Mechanisms Of Signal Transduction] Dissecting the Facilitator and Inhibitor Allosteric Metal Sites of the P2X4 Receptor Channel: CRITICAL ROLES OF CYS132 FOR ZINC POTENTIATION AND ASP138 FOR COPPER INHIBITION
- [Metabolism and Bioenergetics] A Point Mutation in atpC1 Raises the Redox Potential of the Arabidopsis Chloroplast ATP Synthase {gamma}-Subunit Regulatory Disulfide above the Range of Thioredoxin Modulation
- [Metabolism and Bioenergetics] Evidence for nifU and nifS Participation in the Biosynthesis of the Iron-Molybdenum Cofactor of Nitrogenase
- [Papers Of The Week] ATP Synthase Activation and Photosynthesis
- [Protein Structure and Folding] Crystal Structure of the Interleukin-15{middle dot}Interleukin-15 Receptor {alpha} Complex: INSIGHTS INTO TRANS AND CIS PRESENTATION
- [Membrane Transport, Structure, Function, and Biogenesis] Controlling the Inhibition of the Sarcoplasmic Ca2+-ATPase by Tuning Phospholamban Structural Dynamics
- [Mechanisms Of Signal Transduction] Binding of Rac1, Rnd1, and RhoD to a Novel Rho GTPase Interaction Motif Destabilizes Dimerization of the Plexin-B1 Effector Domain
- [Mechanisms Of Signal Transduction] Abnormal Taste Perception in Mice Lacking the Type 3 Inositol 1,4,5-Trisphosphate Receptor
- [Mechanisms Of Signal Transduction] Modulation of F-actin Rearrangement by the Cyclic AMP/cAMP-dependent Protein Kinase (PKA) Pathway Is Mediated by MAPK-activated Protein Kinase 5 and Requires PKA-induced Nuclear Export of MK5
- [Mechanisms Of Signal Transduction] Control of Phenotypic Plasticity of Smooth Muscle Cells by Bone Morphogenetic Protein Signaling through the Myocardin-related Transcription Factors
- [Enzyme Catalysis and Regulation] Acetyl-lysine Analog Peptides as Mechanistic Probes of Protein Deacetylases
- [Membrane Transport, Structure, Function, and Biogenesis] Precursor Protein Is Readily Degraded in Mitochondrial Matrix Space if the Leader Is Not Processed by Mitochondrial Processing Peptidase
- [Protein Synthesis, Post-Translational Modification, and Degradation] BAG-1 Associates with Hsc70{middle dot}Tau Complex and Regulates the Proteasomal Degradation of Tau Protein
- [Molecular Basis Of Cell and Developmental Biology] Heat Shock Transcription Factor 1 Is Required for Maintenance of Ciliary Beating in Mice
- [Protein Structure and Folding] Crystal Structures of Blasticidin S Deaminase (BSD): IMPLICATIONS FOR DYNAMIC PROPERTIES OF CATALYTIC ZINC
- [Dna: Replication, Repair, Recombination, and Chromosome Dynamics] Saccharomyces cerevisiae MutL{alpha} Is a Mismatch Repair Endonuclease
- [Mechanisms Of Signal Transduction] Bone Morphogenetic Protein 2 Opposes Shh-mediated Proliferation in Cerebellar Granule Cells through a TIEG-1-based Regulation of Nmyc
- [Protein Structure and Folding] The Lipid Droplet Binding Domain of Hepatitis C Virus Core Protein Is a Major Determinant for Efficient Virus Assembly
- [Lipids and Lipoproteins] The Cellular Functions of the Yeast Lipin Homolog Pah1p Are Dependent on Its Phosphatidate Phosphatase Activity
- [Protein Structure and Folding] Solution Structure of Selenoprotein W and NMR Analysis of Its Interaction with 14-3-3 Proteins
- [Protein Synthesis, Post-Translational Modification, and Degradation] Cell Type-specific Functions of the Lysosomal Protease Cathepsin L in the Heart
- [Molecular Basis Of Cell and Developmental Biology] Znt7 (Slc30a7)-deficient Mice Display Reduced Body Zinc Status and Body Fat Accumulation
- [Mechanisms Of Signal Transduction] Calcineurin Promotes Hypoxia-inducible Factor 1{alpha} Expression by Dephosphorylating RACK1 and Blocking RACK1 Dimerization
- [Enzyme Catalysis and Regulation] Asparatic Acid 221 Is Critical in the Calcium-induced Modulation of the Enzymatic Activity of Human Aminopeptidase A
- [Lipids and Lipoproteins] Hypermethylation of Fads2 and Altered Hepatic Fatty Acid and Phospholipid Metabolism in Mice with Hyperhomocysteinemia
- [Transcription, Chromatin, and Epigenetics] I{kappa}B-{alpha} Represses the Transcriptional Activity of the HIV-1 Tat Transactivator by Promoting Its Nuclear Export
- [Protein Structure and Folding] A Novel Structural Fold in Polysaccharide Lyases: BACILLUS SUBTILIS FAMILY 11 RHAMNOGALACTURONAN LYASE YesW WITH AN EIGHT-BLADED -PROPELLER
- [Molecular Basis Of Cell and Developmental Biology] The Pancreatitis-induced Vacuole Membrane Protein 1 Triggers Autophagy in Mammalian Cells
- [Protein Structure and Folding] The Active Site of an Algal Prolyl 4-Hydroxylase Has a Large Structural Plasticity
- [Mechanisms Of Signal Transduction] The Functional Role of an Interleukin 6-inducible CDK9{middle dot}STAT3 Complex in Human {gamma}-Fibrinogen Gene Expression
- [Mechanisms Of Signal Transduction] Live-cell Molecular Analysis of Akt Activation Reveals Roles for Activation Loop Phosphorylation
- [Protein Structure and Folding] The Crystal Structure of D7r4, a Salivary Biogenic Amine-binding Protein from the Malaria Mosquito Anopheles gambiae
- [Protein Structure and Folding] Isolating the Epstein-Barr Virus gp350/220 Binding Site on Complement Receptor Type 2 (CR2/CD21)
- [Transcription, Chromatin, and Epigenetics] The Human Monocytic Leukemia Zinc Finger Histone Acetyltransferase Domain Contains DNA-binding Activity Implicated in Chromatin Targeting
- [Glycobiology and Extracellular Matrices] Expression of Bisecting Type and Lewisx/Lewisy Terminated N-Glycans on Human Sperm
- [Transcription, Chromatin, and Epigenetics] A Tunable Ratchet Driving Human RNA Polymerase II Translocation Adjusted by Accurately Templated Nucleoside Triphosphates Loaded at Downstream Sites and by Elongation Factors
- [Mechanisms Of Signal Transduction] Connective Tissue Growth Factor Is Overexpressed in Esophageal Squamous Cell Carcinoma and Promotes Tumorigenicity through -Catenin-T-cell Factor/Lef Signaling
- [Protein Synthesis, Post-Translational Modification, and Degradation] OS-9 Regulates the Transit and Polyubiquitination of TRPV4 in the Endoplasmic Reticulum
- [Protein Structure and Folding] Crystal Structure of the Non-heme Iron Dioxygenase PtlH in Pentalenolactone Biosynthesis
- [Metabolism and Bioenergetics] Regulation of Iron Homeostasis Mediated by the Heme-binding Protein Dap1 (Damage Resistance Protein 1) via the P450 Protein Erg11/Cyp51
- [Membrane Transport, Structure, Function, and Biogenesis] Phosphatidylinositol 4-Phosphate 5-Kinase Reduces Cell Surface Expression of the Epithelial Sodium Channel (ENaC) in Cultured Collecting Duct Cells
- [Metabolism and Bioenergetics] A Role for the Transcriptional Coactivator PGC-1{alpha} in Muscle Refueling
- [Protein Structure and Folding] DyP, a Unique Dye-decolorizing Peroxidase, Represents a Novel Heme Peroxidase Family: ASP171 REPLACES THE DISTAL HISTIDINE OF CLASSICAL PEROXIDASES
- [Lipids and Lipoproteins] Tuning of the Outer Hair Cell Motor by Membrane Cholesterol
- [Papers Of The Week] Salmonella: Killing Macrophages via Glycolysis Enzymes
- [Molecular Basis Of Cell and Developmental Biology] Induction of Nuclear Translocation of Constitutive Androstane Receptor by Peroxisome Proliferator-activated Receptor {alpha} Synthetic Ligands in Mouse Liver
- [Molecular Basis Of Cell and Developmental Biology] Activin Regulates Estrogen Receptor Gene Expression in the Mouse Ovary
- [Mechanisms Of Signal Transduction] Ebp1 Association with Nucleophosmin/B23 Is Essential for Regulating Cell Proliferation and Suppressing Apoptosis
- [Protein Structure and Folding] In-cell Aggregation of a Polyglutamine-containing Chimera Is a Multistep Process Initiated by the Flanking Sequence
- [Protein Structure and Folding] Resistance to Neutralization by Antibodies Targeting the Coiled Coil of Fusion-active Envelope Is a Common Feature of Retroviruses
- [Protein Synthesis, Post-Translational Modification, and Degradation] Autosomal Ichthyosis with Hypotrichosis Syndrome Displays Low Matriptase Proteolytic Activity and Is Phenocopied in ST14 Hypomorphic Mice
- [Protein Structure and Folding] Highly Promiscuous Nature of Prion Polymerization
- [Membrane Transport, Structure, Function, and Biogenesis] Role of TASK2 in the Control of Apoptotic Volume Decrease in Proximal Kidney Cells
- [Membrane Transport, Structure, Function, and Biogenesis] Clustering of Membrane Raft Proteins by the Actin Cytoskeleton
- [Protein Synthesis, Post-Translational Modification, and Degradation] A Suppressive Role of the Prolyl Isomerase Pin1 in Cellular Apoptosis Mediated by the Death-associated Protein Daxx
- [Protein Synthesis, Post-Translational Modification, and Degradation] Hemin Interactions and Alterations of the Subcellular Localization of Prion Protein
- [Transcription, Chromatin, and Epigenetics] Sumoylation-dependent Control of Homotypic and Heterotypic Synergy by the Kruppel-type Zinc Finger Protein ZBP-89
- [Metabolism and Bioenergetics] Metabolism and Elimination of the Endogenous DNA Adduct, 3-(2-Deoxy- -D-erythropentofuranosyl)-pyrimido[1,2-{alpha}]purine-10(3H)-one, in the Rat
- [Rna: Processing and Catalysis] Heterogeneous Ribonucleoprotein M Is a Splicing Regulatory Protein That Can Enhance or Silence Splicing of Alternatively Spliced Exons
- [Metabolism and Bioenergetics] Intake of Sucrose-sweetened Water Induces Insulin Resistance and Exacerbates Memory Deficits and Amyloidosis in a Transgenic Mouse Model of Alzheimer Disease
- [Protein Synthesis, Post-Translational Modification, and Degradation] Proteolysis of the Membrane Type-1 Matrix Metalloproteinase Prodomain: IMPLICATIONS FOR A TWO-STEP PROTEOLYTIC PROCESSING AND ACTIVATION
- [Mechanisms Of Signal Transduction] Identification of a Calmodulin-binding NAC Protein as a Transcriptional Repressor in Arabidopsis
- [Membrane Transport, Structure, Function, and Biogenesis] Differential Activities of Glucocorticoid-induced Leucine Zipper Protein Isoforms
- [Protein Structure and Folding] Selection of Genetically Encoded Fluorescent Single Domain Antibodies Engineered for Efficient Expression in Escherichia coli
- [Mechanisms Of Signal Transduction] The Caspase-1 Digestome Identifies the Glycolysis Pathway as a Target during Infection and Septic Shock
- [Lipids and Lipoproteins] Transfer of Monomeric Endotoxin from MD-2 to CD14: CHARACTERIZATION AND FUNCTIONAL CONSEQUENCES
- [Mechanisms Of Signal Transduction] Critical Role of the Phosphatidylinositol 3-Kinase/Akt/Glycogen Synthase Kinase-3 Signaling Pathway in Recovery from Anthrax Lethal Toxin-induced Cell Cycle Arrest and MEK Cleavage in Macrophages
- [Membrane Transport, Structure, Function, and Biogenesis] The Leader Peptide of Yeast Atp6p Is Required for Efficient Interaction with the Atp9p Ring of the Mitochondrial ATPase
- [Mechanisms Of Signal Transduction] Role for KAP1 Serine 824 Phosphorylation and Sumoylation/Desumoylation Switch in Regulating KAP1-mediated Transcriptional Repression
- [Mechanisms Of Signal Transduction] NRAMP-1 Expression Modulates Protein-tyrosine Phosphatase Activity in Macrophages: IMPACT ON HOST CELL SIGNALING AND FUNCTIONS
- [Mechanisms Of Signal Transduction] Regulation of Peroxiredoxins by Nitric Oxide in Immunostimulated Macrophages
- [Membrane Transport, Structure, Function, and Biogenesis] Twin Arginine Translocation (Tat)-dependent Export in the Apparent Absence of TatABC or TatA Complexes Using Modified Escherichia coli TatA Subunits That Substitute for TatB
- [Transcription, Chromatin, and Epigenetics] Runx2- and Histone Deacetylase 3-mediated Repression Is Relieved in Differentiating Human Osteoblast Cells to Allow High Bone Sialoprotein Expression
- [Mechanisms Of Signal Transduction] NHERF1 Regulates Parathyroid Hormone Receptor Membrane Retention without Affecting Recycling
- [Mechanisms Of Signal Transduction] NOD2 Pathway Activation by MDP or Mycobacterium tuberculosis Infection Involves the Stable Polyubiquitination of Rip2
- [Mechanisms Of Signal Transduction] Hypoxia-inducible Factor-1 Mediates Neuronal Expression of the Receptor for Advanced Glycation End Products following Hypoxia/Ischemia
- [Protein Structure and Folding] Selective Incorporation of Polyanionic Molecules into Hamster Prions
- [Molecular Basis Of Cell and Developmental Biology] Osteocrin Is a Specific Ligand of the Natriuretic Peptide Clearance Receptor That Modulates Bone Growth
- [Mechanisms Of Signal Transduction] Shp2E76K Mutant Confers Cytokine-independent Survival of TF-1 Myeloid Cells by Up-regulating Bcl-XL
- [Mechanisms Of Signal Transduction] The Role of the N Terminus and Transmembrane Domain of TRPM8 in Channel Localization and Tetramerization
- [Membrane Transport, Structure, Function, and Biogenesis] Molecular Proximity of Cystic Fibrosis Transmembrane Conductance Regulator and Epithelial Sodium Channel Assessed by Fluorescence Resonance Energy Transfer
- [Protein Structure and Folding] Stabilization of an Immunoglobulin Fold Domain by an Engineered Disulfide Bond at the Buried Hydrophobic Region
- [Enzyme Catalysis and Regulation] A Novel Calmodulin-Ca2+ Target Recognition Activates the Bcl-2 Regulator FKBP38
- [Enzyme Catalysis and Regulation] Identification of Aspartic Acid and Histidine Residues Mediating the Reaction Mechanism and the Substrate Specificity of the Human UDP-glucuronosyltransferases 1A
- [Protein Structure and Folding] Three-dimensional Structure of the EphB2 Receptor in Complex with an Antagonistic Peptide Reveals a Novel Mode of Inhibition
- [Protein Synthesis, Post-Translational Modification, and Degradation] Regulation of Protein Arginine Methyltransferase 8 (PRMT8) Activity by Its N-terminal Domain
- [Metabolism and Bioenergetics] Substitution of Tyrosine 146 in the dI Component of Proton-translocating Transhydrogenase Leads to Reversible Dissociation of the Active Dimer into Inactive Monomers
- [Dna: Replication, Repair, Recombination, and Chromosome Dynamics] Structure and Activity of Y-class DNA Polymerase DPO4 from Sulfolobus solfataricus with Templates Containing the Hydrophobic Thymine Analog 2,4-Difluorotoluene
- [Membrane Transport, Structure, Function, and Biogenesis] TBC1D20 Is a Rab1 GTPase-activating Protein That Mediates Hepatitis C Virus Replication
- [Mechanisms Of Signal Transduction] Down-regulation of Phosphoglucose Isomerase/Autocrine Motility Factor Expression Sensitizes Human Fibrosarcoma Cells to Oxidative Stress Leading to Cellular Senescence
- [Molecular Basis Of Cell and Developmental Biology] Spatiotemporal Expression of Ameloblastin Isoforms during Murine Tooth Development
- [Enzyme Catalysis and Regulation] The Molecular Basis for Inhibition of BphD, a C-C Bond Hydrolase Involved in Polychlorinated Biphenyls Degradation: LARGE 3-SUBSTITUENTS PREVENT TAUTOMERIZATION
- [Transcription, Chromatin, and Epigenetics] Daxx-like Protein of Drosophila Interacts with Dmp53 and Affects Longevity and Ark mRNA Level
- [Enzyme Catalysis and Regulation] The Essential Cell Division Protein FtsN Interacts with the Murein (Peptidoglycan) Synthase PBP1B in Escherichia coli
- [Dna: Replication, Repair, Recombination, and Chromosome Dynamics] Metal-catalyzed Oxidation of the Werner Syndrome Protein Causes Loss of Catalytic Activities and Impaired Protein-Protein Interactions
- [Mechanisms Of Signal Transduction] An Auto-regulatory Loop between Stress Sensors INrf2 and Nrf2 Controls Their Cellular Abundance
- [Classics] The Conversion of Phenylalanine to Tyrosine: the Work of Seymour Kaufman
- [Minireviews] Actin Structure and Function: What We Still Do Not Understand
- [Accelerated Publications] Gain-of-function Mutation in TRPML3 Causes the Mouse Varitint-Waddler Phenotype
- [Molecular Basis Of Cell and Developmental Biology] A Novel CpG-free Vertebrate Insulator Silences the Testis-specific SP-10 Gene in Somatic Tissues: ROLE FOR TDP-43 IN INSULATOR FUNCTION
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