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Apoptosis, Autophagy, and Necrosis Forum Discuss and post questions about Apoptosis, Programmed Cell Death, Necrosis, Autophagy, and other forms of cell death.


What causes apoptosis?

What causes apoptosis? - Apoptosis, Autophagy, and Necrosis Forum

What causes apoptosis? - Discuss and post questions about Apoptosis, Programmed Cell Death, Necrosis, Autophagy, and other forms of cell death.


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Old 01-28-2014, 10:23 AM
Pipette Filler
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Default What causes apoptosis?



I'm just curious honestly. All I know is that when you ventilate someone with 100% O2 after they've been oxygen deprived it may cause the cells to initiate apoptosis. I was wondering what the mechanism behind this is. Thank you!
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Old 01-28-2014, 10:23 AM
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Apoptosis in general is programmed cell death, which sounds bad, but is actually good. It presents cancer from forming (which is basically a collection of cells that won't die and keep proliferating). There are many chemical pathways that induce apoptosis, so it is kind of difficult to answer this question. However, in short, oxygen is actually poisonous to our body. It oxidizes (as the name suggests) many things in our cells which can trigger apoptosis. For instance, DNA can be oxidized which damages it. This triggers the cell to realize there is a problem and it activates transcription factors to start the death process. This is just one simple explanation.
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Old 02-04-2014, 08:34 AM
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Default Re: What causes apoptosis?

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